Review
Version 1
Preserved in Portico This version is not peer-reviewed
Parenteral Iron Therapy for Pediatric Patients
Version 1
: Received: 17 November 2023 / Approved: 17 November 2023 / Online: 20 November 2023 (02:41:19 CET)
A peer-reviewed article of this Preprint also exists.
Mantadakis, E.; Alexiadou, S.; Zikidou, P. Parenteral Iron Therapy for Pediatric Patients. Hemato 2024, 5, 35-47. Mantadakis, E.; Alexiadou, S.; Zikidou, P. Parenteral Iron Therapy for Pediatric Patients. Hemato 2024, 5, 35-47.
Abstract
Iron deficiency (ID) is by far the most common nutritional disorder in developing and developed countries. When left untreated, ID leads to anemia. Although the usual recommended treatment for iron deficiency anemia (IDA) is oral iron therapy with countless products, such therapy necessitates administration for >3-6 months with questionable patient compliance since most oral iron products have an unpleasant metallic aftertaste and cause intestinal side effects. In addition, in certain gastrointestinal conditions, such as inflammatory bowel diseases or untreated gluten-sensitive enteropathy, oral iron therapy is contraindicated or unsuccessful. Intravenous iron is considered safe in adults, where adverse events are mild and easily managed. The experience with parenteral iron in children is much more limited and many pediatricians appear reluctant to use it because of uncorroborated fears of serious anaphylactic reactions. In the current article, we thoroughly review the available pediatric literature on the use of all commercially available parenteral iron products except ferumoxytol, which was recently removed from the market. We conclude that parenteral iron appears to be safe in children, it works faster than oral iron and the newer third-generation products allow replacement of the total iron deficit at a single setting.
Keywords
iron deficiency; iron deficiency anemia; intravenous iron; iron sucrose; ferric carboxymaltose; iron isomaltoside; inflammatory bowel diseases
Subject
Medicine and Pharmacology, Hematology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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