Article
Version 1
Preserved in Portico This version is not peer-reviewed
Ergodicity Breaking and Self-Destruction of Cancer Cells by Induced Genome Chaos
Version 1
: Received: 27 November 2023 / Approved: 28 November 2023 / Online: 28 November 2023 (10:09:44 CET)
A peer-reviewed article of this Preprint also exists.
Shityakov, S.; Kravtsov, V.; Skorb, E.V.; Nosonovsky, M. Ergodicity Breaking and Self-Destruction of Cancer Cells by Induced Genome Chaos. Entropy 2024, 26, 37. Shityakov, S.; Kravtsov, V.; Skorb, E.V.; Nosonovsky, M. Ergodicity Breaking and Self-Destruction of Cancer Cells by Induced Genome Chaos. Entropy 2024, 26, 37.
Abstract
During the progression of cancer cells, the degree of genome instability increases leading to genome chaos in populations of malignant cells. While normally chaos is associated with er-godicity, i.e., the state when the time averages of relevant parameters is equal to their phase space averages, the situation with cancer propagation is more complex. Chromothripsis, a catastrophic massive genomic rearrangement, is observed in many types of cancer leading to increased mu-tation rates. We present an entropic model of genome chaos and ergodicity and experimental evidence that increasing the degree of chaos beyond the non-ergodic threshold may lead to the self-destruction of the tumor cells. We study time and population averages of chromothripsis frequency in cloned rhabdomyosarcoma from rat stem cells. Clones with frequency above 10% result in cell apoptosis possibly due to mutations in the BCL2 gene. Potentially this can be used for suppressing cancer cells by shifting them into a non-ergodic proliferation regime.
Keywords
cancer; ergodicity; BCL2; mutation rate; chromothripsis; rhabdomyosarcoma; genome chaos
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment