Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Synergistic Effect of Extracellular Vesicles and Nanoquercetin As Anticancer Therapeutics in Hepatocellular Carcinoma

Version 1 : Received: 30 November 2023 / Approved: 30 November 2023 / Online: 1 December 2023 (03:08:11 CET)

A peer-reviewed article of this Preprint also exists.

Raghav, A.; Jeong, G.B. Nanoquercetin and Extracellular Vesicles as Potential Anticancer Therapeutics in Hepatocellular Carcinoma. Cells 2024, 13, 638. Raghav, A.; Jeong, G.B. Nanoquercetin and Extracellular Vesicles as Potential Anticancer Therapeutics in Hepatocellular Carcinoma. Cells 2024, 13, 638.

Abstract

Over the few decades, cancer-associated mortalities and morbidities were continuously increased worldwide despite sophisticated technological advancements. Pharmaceutical interventions associated with drugs exhibit a high degree of side effects and toxicities in addition to very high costs. Subsequently, to reduce or to vanish the side effects and high costs, researchers are now exploring natural bioactive compounds such as quercetin in its nanoformulations along with biologics as cargo delivery vehicles. Quercetin along with mesenchymal stromal lineage-derived extracellular vesicles (EVs) possesses an anti-cancer potential that can be explored to treat hepatocellular carcinoma (HCC). Exerting enhanced effect, nano quercetin synergistically with EVs triggers the anti-cancer mechanisms by regulating and dysregulating several signalling mechanisms including NF-κB, p53, JAK/STAT, MAPK, Wnt/β-catenin and PI3K/AKT, in addition to PBX3/ERK1/2/CDK2, and miRNAs modulation. In addition, findings regarding the potential checkpoints of anti-cancer signalling pathways were investigated that offer opportunities to develop engineered EVs incorporated with nano quercetin for the development of novel therapeutics to treat HCC in future. In this present mechanistic review, we abridged the regulation of such signalling mechanisms synergetic approach of nano quercetin and EVs. The regulatory role of EVs in the manifestation of innumerable miRNAs has also been tailed with special context to HCC.

Keywords

nanoquercetin; extracellular vesicles; hepatocellular carcinoma; therapeutics; anticancer; drug delivery

Subject

Medicine and Pharmacology, Oncology and Oncogenics

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