Hincu, M.-A.; Zonda, G.-I.; Vicoveanu, P.; Harabor, V.; Harabor, A.; Carauleanu, A.; Melinte-Popescu, A.-S.; Melinte-Popescu, M.; Mihalceanu, E.; Stuparu-Cretu, M.; Vasilache, I.-A.; Nemescu, D.; Paduraru, L. Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children2024, 11, 124.
Hincu, M.-A.; Zonda, G.-I.; Vicoveanu, P.; Harabor, V.; Harabor, A.; Carauleanu, A.; Melinte-Popescu, A.-S.; Melinte-Popescu, M.; Mihalceanu, E.; Stuparu-Cretu, M.; Vasilache, I.-A.; Nemescu, D.; Paduraru, L. Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children 2024, 11, 124.
Hincu, M.-A.; Zonda, G.-I.; Vicoveanu, P.; Harabor, V.; Harabor, A.; Carauleanu, A.; Melinte-Popescu, A.-S.; Melinte-Popescu, M.; Mihalceanu, E.; Stuparu-Cretu, M.; Vasilache, I.-A.; Nemescu, D.; Paduraru, L. Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children2024, 11, 124.
Hincu, M.-A.; Zonda, G.-I.; Vicoveanu, P.; Harabor, V.; Harabor, A.; Carauleanu, A.; Melinte-Popescu, A.-S.; Melinte-Popescu, M.; Mihalceanu, E.; Stuparu-Cretu, M.; Vasilache, I.-A.; Nemescu, D.; Paduraru, L. Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children 2024, 11, 124.
Abstract
(1) Background: Neonatal early-onset sepsis (EOS) is associated with important mortality and morbidity. The aims of this study were to evaluate the association between serum biomarkers with early onset neonatal sepsis in a cohort of patients with prolonged rupture of membranes (PROM), and to calculate their diagnostic accuracy. (2) Methods: A retrospective cohort study was conducted on 1355 newborns with PROM admitted between January 2017 and March 2020, who were divided in two groups: group A, with PROM ≥ 18 hours and group B, with PROM < 18 hours. Both groups were further split into subgroups: proven sepsis, probable sepsis and no sepsis. Descriptive statistics, ANOVA analysis, and a Random Effects Generalized Least Squares (GLS) regression were used to evaluate the data. (3) Results: The statistically significant predictors of neonatal sepsis were the high white blood cells count from the first (p = 0.005) and third day (p = 0.028), and high CRP values from the first day (p = 0.004). Procalcitonin (area under the curve - AUC = 0.78) and CRP (AUC = 0.76) measured on the first day had the best predictive performance for early onset neonatal sepsis. (4) Conclusions: Further studies are needed to explore other bi-omarkers of sepsis in both pregnant women and newborns to better predict EOS.
Keywords
Early-onset sepsis; Biomarker; C-reactive protein; Procalcitonin; White blood count; Antibiotics
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
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