Preprint Short Note Version 1 Preserved in Portico This version is not peer-reviewed

9-Ethyl-6,6-Dimethyl-8-[4-(Morpholin-4-Yl)piperidin-1-Yl]-11-Oxo-6,11-Dihydro-5H-Benzo[b]carbazole-3-Carbonitrile Hydrochloride

Version 1 : Received: 11 December 2023 / Approved: 12 December 2023 / Online: 12 December 2023 (09:55:16 CET)

A peer-reviewed article of this Preprint also exists.

Buikin, P.A.; Vologzhanina, A.V.; Novikov, R.A.; Korlyukov, A.A. 9-Ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile Hydrochloride. Molbank 2024, 2024, M1759. Buikin, P.A.; Vologzhanina, A.V.; Novikov, R.A.; Korlyukov, A.A. 9-Ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile Hydrochloride. Molbank 2024, 2024, M1759.

Abstract

Alectinib hydrochloride is an anticancer medication used for the first-line treatment of non-small cell lung cancer. Although it has been approved for medical use ten years ago, and three polymorphs of this substance were proposed based on X-ray diffraction patterns, their crystal structures remained unknown to date. The main problem was preparation of high quality single crystals due to very low solubility of the salt. Herein we report on molecular and crystal structure of form I of alectinib hydrochloride as obtained by powder X-ray diffraction data from laboratory source. The refinement revealed that the nitrogen atom of the morpholinyl ring is protonated. The chloride anion interacts with the H(N) atoms of the morpholine and benzo[b]carbazole rings to form infinite H-bonded chains.

Keywords

active pharmaceutical ingredient; alectinib; half uncertainty window; polymorphism; powder X-ray diffraction

Subject

Chemistry and Materials Science, Medicinal Chemistry

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