Sotomayor-Lugo, F.; Iglesias-Barrameda, N.; Castillo-Aleman, Y.M.; Casado-Hernandez, I.; Villegas-Valverde, C.A.; Bencomo-Hernandez, A.A.; Ventura-Carmenate, Y.; Rivero-Jimenez, R.A. The Dynamics of Histone Modifications during Mammalian Zygotic Genome Activation. Int. J. Mol. Sci.2024, 25, 1459.
Sotomayor-Lugo, F.; Iglesias-Barrameda, N.; Castillo-Aleman, Y.M.; Casado-Hernandez, I.; Villegas-Valverde, C.A.; Bencomo-Hernandez, A.A.; Ventura-Carmenate, Y.; Rivero-Jimenez, R.A. The Dynamics of Histone Modifications during Mammalian Zygotic Genome Activation. Int. J. Mol. Sci. 2024, 25, 1459.
Sotomayor-Lugo, F.; Iglesias-Barrameda, N.; Castillo-Aleman, Y.M.; Casado-Hernandez, I.; Villegas-Valverde, C.A.; Bencomo-Hernandez, A.A.; Ventura-Carmenate, Y.; Rivero-Jimenez, R.A. The Dynamics of Histone Modifications during Mammalian Zygotic Genome Activation. Int. J. Mol. Sci.2024, 25, 1459.
Sotomayor-Lugo, F.; Iglesias-Barrameda, N.; Castillo-Aleman, Y.M.; Casado-Hernandez, I.; Villegas-Valverde, C.A.; Bencomo-Hernandez, A.A.; Ventura-Carmenate, Y.; Rivero-Jimenez, R.A. The Dynamics of Histone Modifications during Mammalian Zygotic Genome Activation. Int. J. Mol. Sci. 2024, 25, 1459.
Abstract
Mammalian fertilization initiates the reprogramming of oocytes and sperm, leading to the formation of a totipotent zygote. The zygotic genome remains transcriptionally silent throughout this intricate process, undergoing the maternal-to-zygotic transition (MZT) and subsequent zygotic genome activation (ZGA). Histone modifications are pivotal in shaping cellular identity and gene expression in many mammals. Recent advances in chromatin analysis enable a detailed exploration of histone modifications during ZGA. This review delves into conserved and unique regulatory strategies, providing essential insights into the dynamic changes in histone modifications and their variants during ZGA in mammals. The objective is to explore recent advancements in leading mechanisms related to histone modifications governing this embryonic development phase in depth. These considerations will be useful for informing future therapeutic approaches that target epigenetic regulation in diverse biological contexts, ranging from regenerative medicine to cancer research. It will also contribute to the extensive areas of evolutionary and developmental biology and possibly lay the foundation for future research and discussion on this seminal topic.
Biology and Life Sciences, Biochemistry and Molecular Biology
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