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Molecular and Cellular Mechanisms of Systemic Autoimmune Diseases: Lessons Learned from Human Genetic Studies and Therapies in Systemic Lupus Erythematosus (SLE)
Version 1
: Received: 29 December 2023 / Approved: 4 January 2024 / Online: 4 January 2024 (07:09:46 CET)
How to cite:
Ling, S.; Fan, R. A. Molecular and Cellular Mechanisms of Systemic Autoimmune Diseases: Lessons Learned from Human Genetic Studies and Therapies in Systemic Lupus Erythematosus (SLE). Preprints2024, 2024010359. https://doi.org/10.20944/preprints202401.0359.v1
Ling, S.; Fan, R. A. Molecular and Cellular Mechanisms of Systemic Autoimmune Diseases: Lessons Learned from Human Genetic Studies and Therapies in Systemic Lupus Erythematosus (SLE). Preprints 2024, 2024010359. https://doi.org/10.20944/preprints202401.0359.v1
Ling, S.; Fan, R. A. Molecular and Cellular Mechanisms of Systemic Autoimmune Diseases: Lessons Learned from Human Genetic Studies and Therapies in Systemic Lupus Erythematosus (SLE). Preprints2024, 2024010359. https://doi.org/10.20944/preprints202401.0359.v1
APA Style
Ling, S., & Fan, R. A. (2024). Molecular and Cellular Mechanisms of Systemic Autoimmune Diseases: Lessons Learned from Human Genetic Studies and Therapies in Systemic Lupus Erythematosus (SLE). Preprints. https://doi.org/10.20944/preprints202401.0359.v1
Chicago/Turabian Style
Ling, S. and R. Andrea Fan. 2024 "Molecular and Cellular Mechanisms of Systemic Autoimmune Diseases: Lessons Learned from Human Genetic Studies and Therapies in Systemic Lupus Erythematosus (SLE)" Preprints. https://doi.org/10.20944/preprints202401.0359.v1
Abstract
A Systemic Lupus Erythematosus (SLE) is a prototypical systemic autoimmune disease characterized by a complex interplay of genetic, molecular, and cellular factors. It is considered a multifactorial disorder influenced by genetic susceptibility, environmental triggers, and dysregulated immune responses. Understanding the molecular and cellular mechanisms driving SLE pathogenesis has been instrumental in developing targeted therapies to manage the disease and improve patient outcomes. In this essay, we will delve into the intricate molecular and cellular processes underlying SLE and examine the key lessons learned from human therapies.
Keywords
Systemic Lupus Erythematosus (SLE); type I interferon response; TACI; BAFF
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.