Version 1
: Received: 6 January 2024 / Approved: 8 January 2024 / Online: 8 January 2024 (10:28:15 CET)
How to cite:
Anikeev, S. G.; Hodorenko, V. N.; Kaftaranova, M. I.; Shabalina, A. V.; Artyukhova, N. V.; Terletskaya, E. N.; Kulinich, S. A.; Pakholkina, S.; Bolshevich, E. A.; Promakhov, V.; Gunther, V. E.; Medvedev, Y. A. Modification of Pore Wall Surface in Shs-Prepared Porous TiNi for Ophthalmic Orbital Implants. Preprints2024, 2024010580. https://doi.org/10.20944/preprints202401.0580.v1
Anikeev, S. G.; Hodorenko, V. N.; Kaftaranova, M. I.; Shabalina, A. V.; Artyukhova, N. V.; Terletskaya, E. N.; Kulinich, S. A.; Pakholkina, S.; Bolshevich, E. A.; Promakhov, V.; Gunther, V. E.; Medvedev, Y. A. Modification of Pore Wall Surface in Shs-Prepared Porous TiNi for Ophthalmic Orbital Implants. Preprints 2024, 2024010580. https://doi.org/10.20944/preprints202401.0580.v1
Anikeev, S. G.; Hodorenko, V. N.; Kaftaranova, M. I.; Shabalina, A. V.; Artyukhova, N. V.; Terletskaya, E. N.; Kulinich, S. A.; Pakholkina, S.; Bolshevich, E. A.; Promakhov, V.; Gunther, V. E.; Medvedev, Y. A. Modification of Pore Wall Surface in Shs-Prepared Porous TiNi for Ophthalmic Orbital Implants. Preprints2024, 2024010580. https://doi.org/10.20944/preprints202401.0580.v1
APA Style
Anikeev, S. G., Hodorenko, V. N., Kaftaranova, M. I., Shabalina, A. V., Artyukhova, N. V., Terletskaya, E. N., Kulinich, S. A., Pakholkina, S., Bolshevich, E. A., Promakhov, V., Gunther, V. E., & Medvedev, Y. A. (2024). Modification of Pore Wall Surface in Shs-Prepared Porous TiNi for Ophthalmic Orbital Implants. Preprints. https://doi.org/10.20944/preprints202401.0580.v1
Chicago/Turabian Style
Anikeev, S. G., Victor E. Gunther and Yuri A. Medvedev. 2024 "Modification of Pore Wall Surface in Shs-Prepared Porous TiNi for Ophthalmic Orbital Implants" Preprints. https://doi.org/10.20944/preprints202401.0580.v1
Abstract
The study focuses on a novel porous TiNi-based material for ophthalmic orbital implants which was produced by self-propagating high-temperature synthesis (SHS) and, after proper surface modification, possesses a specific microstructure of its surface pores, which makes it attractive for biomedical use in implants. After preparation via SHS, the obtained porous TiNi material was etched in acidic environment, to get rid of its surface Ti2Ni secondary-phase particles. This was found to improve the material’s surface morphology, adding micro-roughness to its macro-rough pores. As a result, cell growth tests conducted on the material demonstrated improved cell adhesion and growth kinetics on such a porous material with improved roughness. Finally, the material was tested in vivo as an ophthalmic orbital implant, demonstrating good biocompatibility, good degree of biointegration with surrounding eyeball tissues, and no signs of rejection after as long as 180 days. Thus, the novel porous TiNi-based material shows promise for its use in ophthalmic implantology, for instanse for manufacturing musculoskeletal stumps of the eyeball after evisceration, as it is biocompatible, has a high tissue-implant integration potential and demonstrates reduced risks of exposure and rejection of the implant.
Keywords
porous TiNi alloy; ophthalmic orbital implants; powder metallurgy; self-propagating high-temperature synthesis, surface modification; biocompatibility; biointegration
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.