Prerpints.org logo
Preprint
Article

Association of Temperament and Character Traits with Suicide Probability, Suicide Attempt and Perceived Stress Level in Patients with Bipolar Disorder

Altmetrics

Downloads

129

Views

92

Comments

0

A peer-reviewed article of this preprint also exists.

Submitted:

10 January 2024

Posted:

11 January 2024

You are already at the latest version

Alerts
Abstract
Bipolar disorder (BD) is a high suicide-risk mental disorder. The purpose of this study was to identify the relationship between temperament and character traits with suicide probability, suicide attempt and perceived stress level in patients with BD. A total of 39 euthymic patients with bipolar disorder who had a history of suicide attempt and 39 euthymic patients without a history of suicide attempt were included in this study. Sociodemographic and clinical data form, Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), The Structured Clinical Interview for DSM-5-Clinician Version (SCID-5/CV), Temperament and Character Inventory (TCI), Perceived Stress Scale (PSS), Suicide Probability Scale were used for obtaining the data. HDRS, PSS and SPS scores of the group comprised of patients who attempted suicide were higher than the other group. There was no significant difference between the group of patients who had attempted suicide and the other group in terms of temperament characteristics. In the group of patients who had attempted suicide, self-directedness (SD) and cooperativeness (CO) scores were lower and self-transcendence (ST) score was higher than the other group. HA and ST were positively and SD negatively associated with SPS scores. In the regression analysis for suicide risk, the factors most associated with suicide risk were high HDRS and low CO score. Low SD in BD, high ST with CO may be associated with suicide attempt. Alongside low SD, high HA and ST may be associated with suicidal ideation. Treating residual depressive symptoms can reduce the risk of suicide.
Keywords: 
Subject: Medicine and Pharmacology  -   Psychiatry and Mental Health

1. Introduction

Bipolar Disorder (BD) is a chronic mental disorder characterized by significant disability and loss of functioning. [1,2]. The mortality risk of individuals with BD is increased compared to the general population. Among these risks, suicide is one of them and it has been reported that the risk is 30 times higher than in the general population, especially without treatment [3]. Between 25-50% of individuals with BD have at least one suicide attempt in their past and 15-20% of these attempts are completed suicides [1,2]. Several risk factors for suicide attempt in these patients were found to be female gender, early onset of the disease, first depressive episode and predominance of depressive episodes, comorbidities of cluster B personality disorder, anxiety disorder, alcohol or substance use disorder, and history of suicide attempt in first-degree relatives [4].
The relationship between mood disorders and temperament and character has been of interest since ancient times, and the concepts of temperament, character and personality have been classified in various ways throughout this historical process. Temperament describes genetically and structurally innate characteristics that do not alter throughout an individual's life. Meanwhile, character broadly refers to learned traits that are acquired through environmental influences and education, and that can change over time and that are learned. On the other hand, personality encompasses the joint contribution of innate temperament and acquired character determinants [5]. Among the people who have contributed the most to the study of temperament and character is Cloninger, who defined personality in terms of two basic components, temperament and character, and developed a psychobiological model. According to the model, temperament is analyzed in 4 sub-dimensions: novelty seeking (NS), harm avoidance (HA), reward dependence (RD), persistence (PS), whereas character is analyzed in 3 sub-dimensions: self-directedness (SD), cooperativeness (CO) and self-transcendence (ST) [6].
A review of the literature has demonstrated that certain temperament and character traits are associated with BD in a situation-independent manner [7]. In previous studies, higher NS and lower PS in temperament subscales and higher ST in character subscale were found in patients diagnosed with BD compared to patients diagnosed with depressive disorder and healthy individuals [8,9,10]; in addition, both higher HA and lower SD were found in mood disorders compared to healthy controls [11]. Pre-illness temperament types were found to have an important role in the clinical development of minor and major mood episodes, including the direction of polarity of acute mood episodes and symptom occurrence. Furthermore, it has been reported that personality traits can significantly influence long-term trajectories and outcomes, including suicidality and other self-mutilative behaviors [9]. Nevertheless, there are different views suggesting that temperament and character traits are a predisposing condition for BD or a manifestation of this disorder [7].
The number of studies investigating temperament and character traits using MCI in patients diagnosed with BD with a history of suicide attempt is limited in the literature [9,12,13,14,15,16]. Engström et al [14] found high HA and RD in patients diagnosed with BD, who had a history of suicide attempt compared to the group without a history of suicide attempt. High HA, low PS and low SD were found in patients with BD who had a history of suicide attempt, whereas low RD and low CO were found in patients with BD who did not have a history of suicide attempt compared to healthy controls. They concluded that HA and PS temperament traits are a risk factor for suicide attempt. Sayin et al [12] and Joyce et al [13] reported that high HA is a risk factor. According to another study conducted in patients who followed up with a diagnosis of BD, low SD and high ST were found in patients who had attempted suicide [15].
Our study aimed to determine whether the group with a history of suicide attempt and the group without a history of suicide attempt differed in terms of temperament and character traits, to evaluate the perceived stress levels and suicide probabilities, and to determine the factors predicting suicide in euthymic patients with bipolar disorder who were followed up with a diagnosis of BD.

2. Materials and Methods

2.1. Sample and Procedure

This study included 51 patients with a history of suicide attempt and 54 patients without a history of suicide attempt who were diagnosed with BD as per DSM-5 diagnostic criteria, were followed in remission for at least 3 months, and were admitted to Mersin University Faculty of Medicine Psychiatry Outpatient Clinic between 01/08/2021 and 01/12/2021. Patients included in the study were informed. Written consent was obtained from the patients who volunteered to participate in the study. The approval for this study was obtained from Mersin University Faculty of Medicine Clinical Research Ethics Committee with the decision dated 28/07/2021 and numbered 2021/512. The inclusion criteria for both groups were determined as being between 18-65 years of age, having at least primary school education, not having received Electroconvulsive Therapy (ECT) in the last 6 months, and having signed the Informed Consent Form.
Following the psychiatric interview according to DSM-5 diagnostic criteria, 5 patients with BD who were determined to be in a depressive state and whose Hamilton Depression Rating Scale score was above 7, 3 patients with comorbid generalized anxiety disorder, and 4 patients who failed to complete the scales were excluded from the study. Among the patients diagnosed with BD without a history of suicide attempt, 3 patients who were identified to be in a depressive state and had a Hamilton Depression Rating Scale above 7, 2 patients with hypomanic symptoms and a Young Mania Rating Scale score above 5, 3 patients with comorbid generalized anxiety disorder, 2 patients with comorbid panic disorder, and 5 patients who failed to complete the scales were excluded from the study. Ultimately, the study was conducted with 39 participants from both groups.

2.1.1. Sample Size

G Power program was employed for calculating the sample size Through the G Power program, the minimum sample size required to reach a statistically significant effect size between the variables was calculated and it was determined that each group should have 35 participants (effect size d = 0.8; alpha = 0.05; power = 0.95; allocation ration N2/N1 = 1).

2.2. Measures

2.2.1. The Sociodemographic and Clinical Data Form

The form included sociodemographic characteristics such as age, gender, marital status, educational status and disease data related to BD of the patients participating in the study and was filled out by the interviewee.

2.2.2. Hamilton Depression Rating Scale (HDRS)

Developed by Max Hamilton, it is a 17-item scale used to measure the severity of depression, rated by the clinician [17]. The higher scores on the scale indicate an increase in the severity of depressive symptoms. The Turkish validity and reliability study of the scale was conducted by Akdemir et al. and Cronbach's alpha value was calculated as 0.75 [18].

2.2.3. Young Mania Rating Scale (YMRS)

The scale developed by Young et al. comprises 11 items, each with 5 levels of symptom severity [19]. The coefficient of linear correlation between the total scores of two independent interviewees was 0.93, whereas the coefficients of linear correlation between the scores of each item ranged between 0.66 and 0.92. The reliability and validity study of the scale in Turkish demonstrated that the internal consistency coefficient was 0.79, the consensus among scale items was 63.3% - 95.5% and kappa values were between 0.114-0.849 [20].

2.2.4. The Structured Clinical Interview for DSM-5-Clinician Version (SCID-5/CV)

This structured interview consists of 32 diagnostic categories with detailed diagnostic criteria and 17 diagnostic categories, including only the exploratory questions [21]. In the validity and reliability study of the SCID-5/CV Turkish version, the kappa coefficients between the interviewers were found to be between 0.65 and 1.00. The patient himself, the family and relatives, medical documents/records, and the healthcare team were accepted as information sources during the diagnostic interviews [22].

2.2.5. Temperament and Character Inventory (TCI)

It is a self-report scale developed by Cloninger and colleagues, consisting of 240 true/false items [23]. This scale measures 3 character (SD, CO, and ST) and 4 temperament (NS, HA, RD, and PS) dimensions. Turkish validity and reliability studies were carried out and Cronbach's alpha values were determined between 0.60-0.85 in the temperament scale and 0.82-0.83 in the character scale.

2.2.6. Perceived Stress Scale (PSS)

It was developed to determine the extent to which life events are perceived as stressful. It is a 5-point Likert-type self-report scale consisting of 14 questions scored from 'never' to 'very often'. The 7 items containing positive statements are reverse scored. The higher scores indicate that the stress perception of the individual is high [25]. The Turkish validity and reliability study of the scale has been completed and there are 10-item and 4-item forms in addition to the 14-item long form, and the Cronbach's alpha value of the 10-item form we used in our study was found to be 0.82 [26].

2.2.7. Suicide Probability Scale (SPS)

It has been developed to evaluate suicide risk in adolescents and adults [27]. It is a self-assessment Likert-type rating scale consisting of 36 items. The scale has 4 sub-dimensions; Social Support/ Self Perception, Anger/ Impulsivity, Hopelessness/ Loneliness, Suicidal Ideation. The adaptation, reliability and validity study of the IOS for the Turkish population was undertaken and Cronbach's alpha coefficient was found to be 0.87 [28].

2.3. Statistical Analysis

The data of the study were encoded in the SPSS-21 program for analysis. The data has been analyzed in terms of outliers, missing values and normality. Since the skewness and kurtosis values were within the range of -3 to +3, it was assumed that the data followed a normal distribution. The sociodemographic and disease-related data of the participants were analyzed by descriptive statistical analyses, the chi-square test of independence was used to determine whether there was a difference in the distribution between groups in terms of these data, group differences in terms of scale scores were analyzed by independent groups t-test, and the relationships between variables were examined by Pearson correlation and logistic regression analyses. The significance level was accepted as 0.05 for all analyses.

3. Results

A total of 39 participants, 24 of whom were female (61.5%) and 15 of whom were male (38.5%), with a history of suicide attempt diagnosed with BD, and a total of 39 individuals, 26 of whom were female (66.7%) and 13 of whom were male (33.3%), without a history of suicide attempt, participated in the study as shown in Table 1. The average age of the group with a history of suicide attempt was 39.59 (SD =12.26), while the average age of the other group was 40.02 (SD =12.33). Considering the distribution in terms of perceived social support, 17.9% of the group with a history of suicide attempt and 43.6% of the participants without a history of suicide attempt reported that the social support they received was sufficient. A statistically significant difference was found between the two groups in terms of social support (p<0.05).
A comparison between the scale scores of the group with a history of suicide attempt and the group without a history of suicide attempt is presented in Table 2. Even though our groups were composed of euthymic patients, according to the analysis results, the group with a history of suicide attempt reported higher HDRS (t = 5.509; p < 0.001), PSS (t = 2.623; p = 0.011) and SPS (t = 2.873; p = 0.005) scores than the other group.
In Table 3, when the group with a history of suicide attempt was compared with the group without a history of suicide attempt in terms of temperament and character traits, the group with a history of suicide attempt reported higher ST (t =2.281; p = 0.025) scores and lower SD (t =-2.860; p= 0.005) and CO (t =-3.176; p= 0.002) scores than the other group. On the other hand, the two groups did not differ in terms of other scales. The differences between the two groups in terms of temperament and character traits are given in Table 3.
Among the patients who attempted suicide, 23 (59%) had attempted suicide once, 7 (18%) had attempted suicide twice, 3 (7.6%) had attempted suicide thrice, 4 (10.2%) had attempted suicide four times, 1 (2.6%) had attempted suicide five times, and 1 (2.6%) had attempted suicide six times. In the group with a history of suicide attempt, a significant positive correlation was found between the number of suicide attempts and HDRS (r= 0.349; p= 0.030) and SPS (r= 0.589; p<0.001). On the other hand, the number of suicide attempts was negatively correlated with SD scores (r = -0.372; p = 0.020) and positively correlated with ST (r = 0.321; p = 0.047). Values related to the results of the analysis are presented in Table 4.
As presented in Table 5, the correlation of temperament and character traits with other variables in the group with a history of suicide attempt revealed that HA scores were correlated with PSS (r=0.426, p=0.007), SPS (r=0.323, p=0, 045), while there was a strong positive correlation between SD and PSS (r=-0.405 p=0.011) and SPS (r=-0.509, p<0.001), and a strong positive correlation between ST and SPS (r=0.411 p<0.001).
In the logistic regression analysis performed to examine the relationship between the scores obtained from the measurement tools used in the study and the history of suicide attempt, the group with a history of suicide attempt was coded as "1" and the other group as "0" for the dependent variable suicide attempt. Before the variables were included in the analysis, 50% of the participants were correctly classified. When the classification percentages were analyzed following the inclusion of the variables in the analysis, 76.9% of those without a history of suicide attempt were correctly classified. Among those with a history of suicide attempt, 82.1% were correctly classified. In total, 79.5% of the participants with and without a history of suicide attempt were correctly classified. While this value was 50% at the baseline, an increase was observed as a result of the variables being added to the model. The independent variables account for 50% of the total variance according to the analysis conducted.
Depression was more associated with the presence of a history of suicide attempt than other variables (B = 0.952; SH = 0.271; p < 0.001). Meanwhile, the scores obtained from the CO subscale were associated with the absence of suicide attempt (B = -0.223; SH = 0.097; p = 0.021). Moreover, it was observed that the other scale scores were not related to the presence or absence of a history of suicide attempt. Values related to the results of the analysis are presented in Table 6.

4. Discussion

Exploring the complex relationship between temperament and character traits and suicide risk is thought to provide data to be used in suicide prevention, treatment and prevention of recurrence. This study aimed to contribute to this field where suicidal behavior is frequently associated with BD by using the TCI, which assesses personality dimensionally in a group of patients diagnosed with BD. It is possible to state that the groups of patients diagnosed with BD with and without suicide attempts did not differ in terms of age, gender, marital status, education level, place of residence and socioeconomic status and that these possible confounding variables were eliminated when comparing these two groups.
In comparative studies with healthy controls, the most frequently repeated finding in terms of temperament characteristics in patients with BD was high HA [5,8,29,30,31,32]. HA high scores are reflected in passive avoidance behaviors such as pessimism, asthenia, fatigue, fear of uncertainty, and easily fatigued. While the studies have methodological differences, the greatest focus has been on high HA among temperament traits, and particular attention has been paid to its association with a diagnosis of depression [5,30,33]. In a meta-analysis conducted in 2016, the effect of mood on some temperament and character dimensions was consistently confirmed. According to this study, there was a negative correlation between euthymia and HA [34]. In a 23-year follow-up study, high HA was found to be a risk factor for depression [35]. Therefore, it is considered that the effect of depression intensity on HA score is important when analyzing the relationship between high HA score and suicide attempt. The absence of a significant difference between high HA and suicide attempts in our study may be related to the fact that our patient group was euthymic and both groups were similar in terms of disease-related variables. Nevertheless, it should be stressed that the lack of a healthy control group was also a limitation of the study. Yet, a correlation was found between the increase in HA scores and suicide probability and perceived stress level. A need for further studies on the relationship between HA temperament trait and suicidal ideation, suicide attempt and perceived stress level in this patient group exists.
No difference was found between the groups in terms of PS temperament trait in our study. It was reported that PS was more common in BD than in healthy controls [15,36,37]. People with low PS temperament are inactive and lazy, give up easily, are modest and unsuccessful [38]. In a previous study, it was underlined that low PS might have a protective role against suicide [15]. Furthermore, the relationship between low PS and suicide is yet to be clarified. Since there was no control group in our study, it can be said that PS temperament trait did not differ between the groups. Individuals with high PS temperament traits are hardworking, diligent, ambitious, determined and perfectionist [38]. It has been reported that high PS makes people more susceptible to anxiety disorders rather than mood disorders and may cause positive or negative emotions depending on other personality traits [39].
Literature findings regarding NS and RD temperament characteristics in patients with BD are contradictory. Although high NS scores were found in some studies on BD and/or suicide [34,40,41,42], no significant difference was found in some studies [15,16]. Even low NS scores were found in some studies [8,32]. In our study, no significant difference was detected between such temperament traits and suicide, indicating that prospective studies with large samples are needed to understand the relationship between these temperament traits and suicide.
The character traits frequently observed in patients with BD are low SD [12,15,43,44,45], low CO [12,44,45] and high ST [15,44,45]. Lower SD scores in the group with suicide attempt define such individuals as having difficulty in fighting against difficulties, weak, fragile, irresponsible, insecure, blaming, unable to establish meaningful internal goals, reactive, avoiding taking responsibility and having low self-esteem [11,23,24]. It has been reported that low SD is critical in discriminating between patients with mental illness and healthy controls [24]. Engström et al. and Sarısoy et al. found low SD levels in patients diagnosed with BD who had a history of suicide attempt [15,16]. Another study examining personality traits as a mediating factor between suicide and sociodemographic data found low SD [29], and another study examining suicide attempters and healthy controls found low SD and low CO [40]. Moreover, the negative correlation between SD scores and PSS and SPS scores in our study suggests that patients diagnosed with BD with lower SD traits may feel more stressed due to difficulties of problem-solving and coping in the face of the difficulties caused by the disease, may feel hopeless easier and may engage in suicidal behavior. Whereas individuals with high SD have high self-esteem, internal focus of control, high problem-solving capacity and coping behaviors [23]. The available data suggest that the group with high SD character traits may be more resistant to suicide.
Those who score low on the CO are described as self-absorbed, critical, intolerant, vengeful and opportunistic. Such individuals tend to disrespect other people's rights and feelings [24,46]. It has been suggested that low SD and CO are indicators of immature defense mechanisms and personality disorder [47,48,49]. Furthermore, Sayın et al. [12] identified low SD and CO in patients with BD accompanying personality disorder. These individuals are more likely to encounter stressors in collectivist societies and the fact that they do not seek help while struggling with these stressors may be the factors that lead them to suicidal behavior. The significantly lower CO levels detected in the group with suicide attempt in our study is consistent with the studies investigating the character profiles of patients with suicide attempt in the literature [40,41]. Individuals who are dominant in this characteristic have been reported to be empathizing, accepting, supportive, fair and collaborating with others as much as possible and enjoy helping others [23,50]. According to regression analyses, high scores obtained from this scale were found to be associated with the absence of suicide attempt. Similar to our study, Pawlak et al. found that CO played a protective role in suicide through a regression analysis [51]. In some longitudinal studies conducted in university students, high CO was found to be protective against suicide [52,53,54]. These findings suggest that high CO, particularly when accompanied by high SD, is associated with resilience in coping with specific stressors and may be a protective factor for stress-related mental disorders [52]. Inherently high CO may contribute as a protective factor against suicide by facilitating more adaptive behavior and cooperation.
The individuals with high ST scores, which is the last character trait, are satisfied, patient and creative. Loftus et al. [45] suggest that high ST accompanying low SD may be an indicator of residual psychotic symptoms. When high ST, low SD and low CO are combined, the individual may develop magical thinking, rich imagination and dissociative tendencies that may be accompanied by personality pathologies (especially schizotypal). In contrast, high CO and high SD accompanying high ST are characterized by positive effects such as maturity, spirituality and creativity [55]. In our study, ST was significantly higher within the group of those who attempted suicide. In addition, we found a correlation between ST score and SPS scores. The condition causing susceptibility to suicide attempt was thought to be related not only to high ST but also to low SD and low CO. These data were also found in similar studies [15,44,45,56]. Meanwhile, individuals with low ST are impatient, lack imagination and humility and are prideful. They cannot tolerate uncertainty or surprises. They wish to have control over almost everything. In Western societies, individuals with low ST are often recognized for their rational, scientific and material achievements. They may have hard time accepting pain and death [23]. The fact that people with low ST character traits are assertive, individualistic, controlling and conscious and have difficulty in accepting death may be a character trait that protects them against suicide.
In the group, composed of individuals who attempted suicide, there was a positive correlation between the number of suicide attempts and HDRS and ST, and a negative correlation with SD. In a prospective study by Jylha et al., the number of suicide attempts, both lifetime and prospectively assessed, was found to be associated with high ST, low SD and CO [31]. The findings are in line with most studies evaluating the association of lifetime suicide attempts with ST, SD and CO among patients with mood disorders [15,16,51,57]. Among these features, the role of SD was found to be central [31].
Logistic regression analysis to examine the relationship between the scores obtained from the measurement tools used in our study and the history of suicide attempt showed that HDRS scores were more associated with the presence of a history of suicide attempt than other variables. Despite the fact that our sample was composed of euthymic patients, some studies have underlined that residual depressive symptoms have a much more negative impact on functioning than residual manic symptoms [58]. Several prospective studies have reported that the main determinant of suicide was time spent during periods of high-risk illness [59,60,61]. The frequency of suicide attempts was found to increase 25 times in major depressive episodes and 65 times in mixed illness episodes when compared to euthymia [61]. Among patients with mood disorders, suicidal acts without any period of illness have been reported to be rare [59,60,61]. Besides, among the other findings of our study, the fact that the HDRS scores of the group with suicide attempts were higher in the correlation analysis and the HDRS scores increased as the number of suicide attempts increased emphasizes the importance of treating residual depressive symptoms, even though they seem to be subthreshold.
The PSS and SPS scores of the group with a history of suicide attempt were significantly higher than the group without suicide attempt. The distal factors that increase the risk of suicide in BD include genetic factors, personality traits, early childhood trauma, cognitive patterns and family history of suicide. As for the proximal causes, there are stressful life events, subjective stress perception of the person, current suicidal ideation, feelings of helplessness and hopelessness. It is possible to state that SPS and PSS can be considered as proximal causes and when there are predisposing distal causes, they may trigger suicidal behavior [62]. Moreover, a correlation was found between the number of suicide attempts and SPS scores. It was observed that suicide attempt in the past was the most important predictor for suicide risk and that 50% of completed suicide cases had one suicide attempt in the past [63]. This indicates that patients with BD may be a group that is prone to suicidal behavior even in euthymic periods.
Since the sample size in our study was relatively small and the study was cross-sectional, it is difficult to determine the cause-and-effect relationship. BD subtypes are not categorized separately, and studies in larger samples are required to determine the effect of different temperament and character traits of BD subtypes on suicide attempts. Patients included in the study mostly consisted of individuals on regular treatment. BD patients who refused treatment, thus did not receive regular drug treatment and did not apply to the outpatient clinic for treatment organization were not included in the study. Untreated BD patients may be at higher risk of suicide than those who accept treatment. This situation restricts the generalization of our findings to all BD patients. The method of suicide was not evaluated in patients with suicide attempt. Not including the completed suicide attempts in the study can be considered as another limitation. Finally, since no healthy control group was available, similar and different aspects of temperament and character traits with BD patients could not be evaluated. A need for future studies with a larger sample size, including a control group, and evaluating temperament and character traits in a way to includes the method of suicide attempt is apparent.

5. Conclusions

Various temperament and character traits may play an important role in determining suicide attempt. Low SD with low CO accompanying high ST may be associated with suicide attempts in BD. Additionally, residual depressive symptoms may be associated with suicide attempts.

Author Contributions

Conceptualization, S.Ö.Y., A.E.Y. and H.Y.; methodology, S.Ö.Y. and A.E.Y.; software, S.Ö.Y. and H.Y.; validation, S.Ö.Y. and A.E.Y.; formal analysis, S.Ö.Y.; investigation, S.Ö.Y and A.E.Y.; resources, S.Ö.Y and H.Y.; data curation, S.Ö.Y.; writing—original draft preparation, S.Ö.Y., A.E.Y. and H.Y.; writing—review and editing, S.Ö.Y., A.E.Y. and H.Y.; visualization, S.Ö.Y. and A.E.Y.; supervision, S.Ö.Y. and H.Y.; project administration, S.Ö.Y. and A.E.Y. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

The study was conducted in accordance with the Decla-ration of Helsinki and approved by the Ethics Committee of Mersin University Faculty of Medicine for Non-Interventional Clinical Research on July 28, 2021 (decision no. 512).

Informed Consent Statement

Written informed consent was obtained from all subjects involved in the study.

Data Availability Statement

The data presented in this study are available on request from the corresponding author.

Acknowledgments

None to declare.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Grande, I.; Berk, M.; Birmaher, B.; Vieta, E. Bipolar disorder. Lancet 2016, 387, 1561–1572. [Google Scholar] [CrossRef]
  2. Valtonen, H.M.; Suominen, K.; Mantere, O.; Leppämäki, S.; Arvilommi, P.; Isometsä, E. Suicidal behaviour during different phases of bipolar disorder. J. Affect. Disord. 2007, 97, 101–107. [Google Scholar] [CrossRef]
  3. Petek Erić, A.; Erić, I.; Ćurković, M.; Dodig-Ćurković, K.; Kralik, K.; Kovač, V.; Filaković, P. The temperament and character traits in patients with major depressive disorder and bipolar affective disorder with and without suicide attempt. Psychiatr. Danub. 2017, 29, 171–178. [Google Scholar] [CrossRef]
  4. Schaffer, A.; Isometsä, E.T.; Tondo, L.; Moreno, D.; Turecki, G.; Reis, C.; Cassidy, F.; Sinyor, M.; Azorin, J.M.; Kessing, L.V.; et al. International Society for Bipolar Disorders Task Force on Suicide: meta-analyses and meta-regression of correlates of suicide attempts and suicide deaths in bipolar disorder. Bipolar Disord. 2015, 17, 1–16. [Google Scholar] [CrossRef] [PubMed]
  5. Akiskal, H.S.; Hirschfeld, R.M.A.; Yerevanian, B.I. The relationship of personality to affective disorders. Arch. Gen. Psychiatry 1983, 40, 801–810. [Google Scholar] [CrossRef] [PubMed]
  6. Cloninger, C.R. A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr. Dev. 1986, 4, 167–226. [Google Scholar] [PubMed]
  7. Savitz, J.B.; Ramesar, R.S. Personality: is it a viable endophenotype for genetic studies of bipolar affective disorder? Bipolar Disord. 2006, 8, 322–337. [Google Scholar] [CrossRef] [PubMed]
  8. Osher, Y.; Lefkifker, E.; Kotler, M. Low persistence in euthymic manicdepressive patients: a replication. J. Affect. Disord. 1999, 53, 87–90. [Google Scholar] [CrossRef] [PubMed]
  9. Izci, F.; Fındıklı, E.K.; Zincir, S.; Zincir, S.B.; Koc, M.I. The differences in temperament–character traits, suicide attempts, impulsivity, and functionality levels of patients with bipolar disorder I and II. Neuropsychiatr. Dis. Treat. 2016, 177–184. [Google Scholar] [CrossRef] [PubMed]
  10. Young, L.T.; Bagby, R.M.; Cooke, R.G.; Parker, J.D.; Levitt, A.J.; Joffe, R.T. A comparison of Tridimensional Personality Questionnaire dimensions in bipolar disorder and unipolar depression. Psychiatr. Res. 1995, 58, 139–143. [Google Scholar] [CrossRef] [PubMed]
  11. Arkar, H.; Sorias, O.; Tunca, Z.; Şafak, C.; Alkın, T.; Binnur Akdede, B.; Şahin, S.; Akvardar, Y.; Sarı, Ö.; Özerdem, A.; et al. Mizaç ve karakter envanteri’nin Türkçe formunun faktör yapısı, geçerlik ve güvenilirliği. Türk Psikiyatri Derg. 2005, 16, 190–204. [Google Scholar] [PubMed]
  12. Sayın, A.; Kuruoğlu, A.C.; Yazıcı Güleç, M.; Aslan, S. Relation of temperament and character properties with clinical presentation of bipolar disorder. Compr. Psychiatry 2007, 48, 446–451. [Google Scholar] [CrossRef] [PubMed]
  13. Joyce, P.R.; Light, K.J.; Rowe, S.L.; Cloninger, C.R.; Kennedy, M.A. Selfmutilation and suicide attempts: relationships to bipolar disorder, borderline personality disorder, temperament and character. Aust. N. Z. J. Psychiatry 2010, 44, 250–257. [Google Scholar] [CrossRef]
  14. Zakowicz, P.; Skibińska, M.; Wasicka-Przewoźna, K.; Skulimowski, B.; Waśniewski, F.; Chorzepa, A.; Różański, M.; Twarowska-Hauser, J.; Pawlak, J. Impulsivity as a risk factor for suicide in bipolar disorder. Front. Psychiatry 2021, 12, 706933. [Google Scholar] [CrossRef]
  15. Sarısoy, G.; Kaçar, Ö.F.; Pazvantoǧlu, O.; Öztürk, A.; Korkmaz, I.Z.; Kocamanoğlu, B.; Böke, O.; Sahin, A.R. Temperament and character traits in patients with bipolar disorder and associations with attempted suicide. Compr. Psychiatry 2012, 53, 1096–1102. [Google Scholar] [CrossRef]
  16. Engström, C.; Brändström, S.; Sigvardsson, S.; Cloninger, C.R.; Nylander, P.O. Bipolar disorder. III: Harm avoidance a risk factor for suicide attempts. Bipolar Disord. 2004, 6, 309–338. [Google Scholar] [CrossRef] [PubMed]
  17. HAMILTON, M. A rating scale for depression. J Neurol. Neurosurg. Psychiatry 1960, 23, 56–62. [Google Scholar] [CrossRef]
  18. Akdemir, A.; Örsel, D.S.; Dağ, İ.; Türkçapar, M.H.; İşcan, N.; Özbay, H. Hamilton Depresyon Derecelendirme Ölçeği (HDDÖ)’nin geçerliliği-güvenilirliği ve klinikte kullanımı. Psikiyatri Psikoloji Psikofarmakoloji Dergisi 1996, 4, 251–259. [Google Scholar]
  19. Young, R.C.; Biggs, J.T.; Ziegler, V.E.; Meyer, D.A. A rating scale for mania: reliability, validity and sensitivity. Br. J. Psychiatry 1978, 133, 429–435. [Google Scholar] [CrossRef]
  20. Karadağ, F.; Oral, E.T.; Aran-Yalçın, F.; Erten, E. Young Mani Derecelendirme Ölçeğinin Türkiye’de Geçerlik ve Güvenilirliği. Türk Psikiyatri Derg. 2001, 13, 107–114. [Google Scholar]
  21. Osório, F.L.; Loureiro, S.R.; Hallak, J.E.C.; Machado-de-Sousa, J.P.; Ushirohira, J.M.; Baes, C.V.W.; Apolinario, T.D.; Donadon, M.F.; Bolsoni, L.M.; Guimarães, T.; et al. Clinical validity and intrarater and test-retest reliability of the Structured Clinical Interview for DSM-5—Clinician Version (SCID-5-CV). Psychiatry Clin. Neurosci. 2019, 73, 754–760. [Google Scholar] [CrossRef]
  22. Elbir, M.; Alp-Topbaş, Ö.; Bayad, S.; Kocabaş, T.; Topak, Ö.Z.; Çetin, Ş.; Özdel, O.; Ateşçi, F.; Aydemir, Ö. DSM-5 Bozuklukları için yapılandırılmış klinik görüşmenin klinisyen versiyonunun türkçeye uyarlanması ve güvenilirlik çalışması. Türk Psikiyatri Derg. 2019, 30, 51–56. [Google Scholar]
  23. Cloninger, C.R.; Svrakic, D.M.; Przybeck, T.R. A psychobiological model of temperament and character. Arch. Gen. Psychiatry 1993, 50(12), 975–990. [Google Scholar] [CrossRef]
  24. Kose, S. A Psychobiological Model of Temperament and Character: TCI. New Symp. 2003, 41, 86–97. [Google Scholar]
  25. Cohen, S.; Kamarck, T.; Mermelstein, R. A global measure of perceived stress. J. Health Soc. Behav. 1983, 24, 385–396. [Google Scholar] [CrossRef] [PubMed]
  26. Eskin, M.; Harlak, H.; Demirkıran, F.; Dereboy, Ç. Algılanan Stres Ölçeğinin Türkçeye Uyarlanması: Güvenirlik ve Geçerlik Analizi. New Symp. 2013, 51, 132–140. [Google Scholar]
  27. Cull, J.G.; Gill, W.S. Suicide Probability Scale. J. Consult. Clin. Psychol. 1988. [Google Scholar]
  28. Durak-Batıgün, A.; Şahin, N.H. İntihar Olasılığı Ölçeği: Gözden geçirme, geçerlik ve güvenirlik çalışması. Klinik Psikoloji Dergisi 2018, 2, 52–64. [Google Scholar]
  29. Grucza, R.A.; Przybeck, T.R.; Cloninger, C.R. Personality as a mediator of demographic risk factors for suicide attempts in a community sample. Compr. Psychiatry 2005, 46, 214–222. [Google Scholar] [CrossRef] [PubMed]
  30. Cloninger, C.R.; Bayon, C.; Svrakic, D.M. Measurement of temperament and character in mood disorders: a model of fundamental states as personality types. J Affect. Disord. 1998, 51, 21–32. [Google Scholar] [CrossRef] [PubMed]
  31. Jylhä, P.J.; Rosenström, T.; Mantere, O.; Suominen, K.; Melartin, T.K.; Vuorilehto, M.S.; Holma, M.K.; Riihimäki, K.A.; Oquendo, M.A.; Keltikangas-Järvinen, L.; et al. Temperament, character, and suicide attempts in unipolar and bipolar mood disorders. J. Clin. Psychiatry 2016, 77, 252–260. [Google Scholar] [CrossRef]
  32. Engström, C.; Brändström, S.; Sigvardsson, S.; Cloninger, R.; Nylander, P.O. Bipolar disorder. II: personality and age of onset. Bipolar Disord. 2003, 5, 340–348. [Google Scholar] [CrossRef] [PubMed]
  33. Balestri, M.; Porcelli, S.; Souery, D.; Kasper, S.; Dikeos, D.; Ferentinos, P.; Papadimitriou, G.N.; Rujescu, D.; Martinotti, G.; Di Ncola, M.; et al. Temperament and character influence on depression treatment outcome. J. Affect. Disord. 2019, 252, 464–474. [Google Scholar] [CrossRef]
  34. Zaninotto, L.; Solmi, M.; Toffanin, T.; Veronese, N.; Cloninger, C.R.; Correll, C.U. A meta-analysis of temperament and character dimensions in patients with mood disorders: Comparison to healthy controls and unaffected siblings. J. Affect. Disord. 2016, 194, 84–97. [Google Scholar] [CrossRef] [PubMed]
  35. Ahola, A.; Rautio, N.; Timonen, M.; Nordström, T.; Jääskeläinen, E.; Miettunen, J. Premorbid temperament as predictor of onset of depression: 23-year follow-up. Compr. Psychiatry 2023, 121, 152359. [Google Scholar] [CrossRef]
  36. Jylhä, P.; Mantere, O.; Melartin, T.; Suominen, K.; Vuorilehto, M.; Arvilommi, P.; Holma, I.; Holma, M.; Leppämäki, S.; Valtonen, H.; et al. Differences in temperament and character dimensions in patients with bipolar I or II or major depressive disorder and general population subjects. Psychol. Med. 2011, 41, 1579–1591. [Google Scholar] [CrossRef]
  37. Olvera, R.L.; Fonseca, M.; Caetano, S.C.; Hatch, J.P.; Hunter, K.; Nicoletti, M.; Pliszka, S.R.; Cloninger, C.R.; Soares, J.C. Assessment of personality dimensions in children and adolescents with bipolar disorder using the Junior Temperament and Character Inventory. J. Child Adolesc. Psychopharmacol. 2009, 19, 13–21. [Google Scholar] [CrossRef]
  38. Cloninger, C.R.; Przybeck, T.R.; Svrakis, D.M.; Wetzel, R.D. The temperament and character inventory (TCI): a guide to its development and use; Washington University, Center of Psychobiology of Personality: St. Louis, MO, 1994. [Google Scholar]
  39. Cloninger, C.R.; Zohar, A.H.; Hirschmann, S.; Dahan, D. The psychological costs and benefits of being highly persistent: personality profiles distinguish mood disorders from anxiety disorders. J. Affect Disord. 2012, 136, 758–766. [Google Scholar] [CrossRef]
  40. Becerra, B.; Páez, F.; Robles-Garcia, R.; Vela, G.E. Temperament and character profile of persons with suicide attempt. Actas Esp. Psiquiatr. 2005, 33, 117–122. [Google Scholar]
  41. Van Heeringen, K.; Audenaert, K.; Van de Wiele, L.; Verstraete, A. Cortisol in violent suicidal behaviour: association with personality and monoaminergic activity. J. Affect. Disord. 2000, 60, 181–189. [Google Scholar] [CrossRef]
  42. Hong, S.; Jeon, H.J.; Ha, J.H. Differences in temperament and character inventory (TCI) profile between suicidal and nonsuicidal psychiatric outpatients. Medicine 2022, 101. [Google Scholar] [CrossRef] [PubMed]
  43. Engström, C.; Brändström, S.; Sigvardsson, S.; Cloninger, R.; Nylander, P.O. Bipolar disorder: I. Temperament and character. J. Affect. Disord. 2004, 82, 131–134. [Google Scholar] [CrossRef] [PubMed]
  44. Evans, L.; Akiskal, H.S.; Keck Jr, P.E.; McElroy, S.L.; Sadovnick, A.D.; Remick, R.A.; Kelsoe, J.R. Familiality of temperament in bipolar disorder: support for a genetic spectrum. J. Affect. Disord. 2005, 85, 153–168. [Google Scholar] [CrossRef]
  45. Loftus, S.T.; Garno, J.L.; Jaeger, J.; Malhotra, A.K. Temperament and character dimensions in bipolar I disorder: a comparison to healthy controls. J. Psychiatr. Res. 2008, 42, 1131–1136. [Google Scholar] [CrossRef] [PubMed]
  46. Cloninger, C.R. A systematic method for clinical description and classification of personality variants. A proposal. Arch. Gen. Psychiatry 1987, 44, 573–588. [Google Scholar] [CrossRef] [PubMed]
  47. Goldman, R.G.; Skodol, A.E.; McGrath, P.J.; Oldham, J.M. Relationship between the Tridimensional Personality Questionnaire and DSM-III-R personality traits. Am. J. Psychiatry 1994, 151, 274–276. [Google Scholar]
  48. Mulder, R.T. Personality pathology and treatment outcome in major depression: a review. Am. J. Psychiatry 2002, 159, 359–371. [Google Scholar] [CrossRef]
  49. Svrakic, D.M.; Draganic, S.; Hill, K.; Bayon, C.; Przybeck, T.R.; Cloninger, C.R. Temperament, character, and personality disorders: etiologic, diagnostic, treatment issues. Acta Psychiatr. Scand. 2002, 106, 189–195. [Google Scholar] [CrossRef]
  50. Cloninger, C.R. Temperament and personality. Curr. Opin. Neurobiol. 1994, 4, 266–273. [Google Scholar] [CrossRef]
  51. Pawlak, J.; Dmitrzak-Weglarz, M.; Skibinska, M.; Szczepankiewicz, A.; Leszczynska-Rodziewicz, A.; Rajewska-Rager, A.; Maciukiewicz, M.; Czerski, P.; Hauser, J. Suicide attempts and psychological risk factors in patients with bipolar and unipolar affective disorder. Gen. Hosp. Psychiatry 2013, 35, 309–313. [Google Scholar] [CrossRef]
  52. Takanobu, K.; Mitsui, N.; Watanabe, S.; Toyoshima, K.; Fujii, Y.; Kako, Y.; Asakura, S.; Kusumi, I. Character configuration, major depressive episodes, and suicide-related ideation among Japanese undergraduates. PLoS One 2021, 16, e0251503. [Google Scholar] [CrossRef]
  53. Mitsui, N.; Asakura, S.; Shimizu, Y.; Fujii, Y.; Kako, Y.; Tanaka, T.; Oba, K.; Inoue, T.; Kusumi, I. Temperament and character profiles of Japanese university students with depressive episodes and ideas of suicide or self-harm: A PHQ-9 screening study. Compr. Psychiatry 2013, 54, 1215–1221. [Google Scholar] [CrossRef] [PubMed]
  54. Mitsui, N.; Asakura, S.; Takanobu, K.; Watanabe, S.; Toyoshima, K.; Kako, Y.; Ito, Y.M.; Kusumi, I. Prediction of major depressive episodes and suicide-related ideation over a 3-year interval among Japanese undergraduates. PLoS One 2018, 13, e0201047. [Google Scholar] [CrossRef] [PubMed]
  55. Cloninger, C.R.; Svrakic, D.M. Personality Disorders. Comprehensive Textbook of Psychiatry, 7th ed.; Sadock, B.J., Sadock., V., Eds.; Williams & Wilkins: Baltimore, 2000. [Google Scholar]
  56. Nery, F.G.; Hatch, J.P.; Glahn, D.C.; Nicoletti, M.A.; Monkul, E.S.; Najt, P.; Fonseca, M.; Bowden, C.L.; Cloninger, C.R.; Soares, J.C. Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders. J. Psychiatr. Res. 2008, 42, 569–577. [Google Scholar] [CrossRef] [PubMed]
  57. Perroud, N.; Baud, P.; Ardu, S.; Krejci, I.; Mouthon, D.; Vessaz, M.; Guillaume, S.; Jaussent, I.; Olie, E.; Malafosse, A.; et al. Temperament personality profiles in suicidal behaviour: an investigation of associated demographic, clinical and genetic factors. J. Affect. Disord. 2013, 146, 246–253. [Google Scholar] [CrossRef]
  58. Malhi, G.S.; Ivanovski, B.; Hadzi-Pavlovic, D.; Mitchell, P.B.; Vieta, E.; Sachdev, P. Neuropsychological deficits and functional impairment in bipolar depression, hypomania and euthymia. Bipolar Disord. 2007, 9, 114–125. [Google Scholar] [CrossRef] [PubMed]
  59. Riihimaki, K.; Vuorilehto, M.; Melartin, T.; Haukka, J.; Isometsä, E. Incidence and predictors of suicide attempts among primary-care patients with depressive disorders: a 5-year prospective study. Psychol. Med. 2014, 44, 291–302. [Google Scholar] [CrossRef] [PubMed]
  60. Valtonen, H.M.; Suominen, K.; Haukka, J.; Mantere, O.; Leppämäki, S.; Arvilommi, P.; Isometsä, E.T. Differences in incidence of suicide attempts during phases of bipolar I and II disorders. Bipolar Disord. 2008, 10, 588–596. [Google Scholar] [CrossRef] [PubMed]
  61. Holma, K.M.; Haukka, J.; Suominen, K.; Valtonen, H.M.; Mantere, O.; Melartin, T.K.; Sokero, T.P.; Oquendo, M.A.; Isometsä, E.T. Differences in incidence of suicide attempts between bipolar I and II disorders and major depressive disorder. Bipolar Disord. 2014, 16, 652–661. [Google Scholar] [CrossRef]
  62. Rudd, M.D.; Berman, A.L.; Joiner Jr, T.E.; Nock, M.K.; Silverman, M.M.; Mandrusiak, M.; Orden, K.V.; Witte, T. Warning signs for suicide: theory, research, and clinical applications. Suicide Life Threat. Behav. 2006, 36, 255–262. [Google Scholar] [CrossRef]
  63. Dome, P.; Rihmer, Z.; Gonda, X. Suicide risk in bipolar disorder: a brief review. Medicina 2019, 55, 403. [Google Scholar] [CrossRef] [PubMed]
Table 1. Comparison of Sociodemographic Characteristics of Bipolar Disorder Patients with and without Suicide Attempts.
Table 1. Comparison of Sociodemographic Characteristics of Bipolar Disorder Patients with and without Suicide Attempts.
Suicide attempt
(n=39)		 Non-suicide attempt
(n=39)
N % N % χ² p
Gender
  Female 24 61.5 26 66.7 0.223 0.637
  Male 15 38.5 13 33.3
Marital status
  Single 26 66.7 20 51.3 1.908 0.167
  Married 13 33.3 19 48.7
Education
  Primary school 15 38.5 8 20.5 3.13 0.209
  High school 9 23.1 13 33.3
  University 15 38.5 18 46.2
Living place
  Smaller than province 8 20.5 6 15.4 0.348 0.555
  Province 31 79.5 33 84.6
Occupational status
  Student 7 17.9 2 5.1 4.003 0.135
  Employed 12 30.8 18 46.2
  Unemployed 20 51.3 19 48.7
People with whom she/he lives
  Alone 6 15.4 1 2.6 6.892 0.075
  Mother-father 18 46.2 13 33.3
  Spouse-children 13 33.3 22 56.4
  Other 2 5.1 3 7.7
Socioeconomic status
  Low 23 59 16 41 2.513 0.113
  Middle 16 41 23 59
Social support
  Sufficient 7 17.9 17 43.6 11.397 0.022*
  Inadequate in some areas 19 48.7 19 48.7
  Inadequate in many areas 11 28.2 2 5.1
  Inadequate in almost every area 1 2.6 1 2.6
  There are none 1 2.6 0 0
Medical illness
  No 22 56.4 20 51.3 0.206 0.65
  Yes 17 43.6 19 48.7
Smoking
  No 16 41 24 61.5 3.284 0.07
  Yes 23 59 15 38.5
*p<0.05.
Table 2. Comparison of YMRS, HDRS, PSS and SPS scores of the groups.
Table 2. Comparison of YMRS, HDRS, PSS and SPS scores of the groups.
Suicide attempt
(n=39)		 Non-suicide attempt
(n=39)
Mean±SD Mean±SD p
YMRS 1.20 ± 1.05 0.95 ± 1.00 0.274
HDRS 3.36 ± 1.53 1.43 ± 1.55 <0.001***
PSS 21.18 ± 7.58 16.79 ± 7.18 0.011*
SPS 75.64 ± 14.52 65.38 ± 16.91 0.005**
*p<0.05,**p<0.01,***p<0.001 YMRS: Young Mania Rating Scale, HDRS: Hamilton Depression Rating Scale, PSS: Perceived Stress Scale, SPS: Suicide Probability Scale, SD: Standard Deviation.
Table 3. Comparison of TCI Scores of Groups.
Table 3. Comparison of TCI Scores of Groups.
Suicide attempt
(n=39)		 Non-suicide attempt
(n=39)
Mean ± SD Mean ± SD p
Novelty seeking 18.69 ± 5.56 17.85 ± 4.55 0.465
 Harm avoidance 20.74 ± 7.19 19.20 ± 6.27 0.317
 Reward dependence 12.92 ± 3.17 13.77 ± 2.84 0.219
 Persistence 4.28 ± 1.83 4.38 ± 1.89 0.808
 Self-directedness 23.69 ± 6.24 28.33 ± 7.98 0.005**
 Cooperativeness 26.13 ± 5.63 30.31 ± 5.98 0.002**
 Self-transcendence 19.74 ± 5.20 16.77 ± 6.27 0.025*
Table 4. The Relationship Between the Number of Suicide Attempts and the Scales in the Group with a History of Suicide Attempts.
Table 4. The Relationship Between the Number of Suicide Attempts and the Scales in the Group with a History of Suicide Attempts.
YMRS HDRS NS HA RD PS SD CO ST PSS SPS
Number of Suicide Attempts r 0.095 0.349 0.105 0.182 0.029 -0.061 -0.372 -0.224 0.321 0.297 0.589
p 0.566 0.030* 0.523 0.267 0.861 0.714 0.020* 0.171 0.047* 0.067 0.000***
*p<0.05, **p<0.01, ***p<0.001, YMRS: Young Mania Rating Scale, HDRS: Hamilton Depression Rating Scale NS: Novelty Seeking, HA: Harm Avoidance, RD: Reward Dependence, PS: Persistence, SD: Self-directedness, CO: Cooperativeness, ST: Self-transcendence, PSS: Perceived Stress Scale, SPS: Suicide Probability Scale.
Table 5. Relationship Between Variables in the Group with a History of Suicide Attempts.
Table 5. Relationship Between Variables in the Group with a History of Suicide Attempts.
YMRS HDRS PSS SPS
NS r 0.307 0.106 -0.076 0.243
p 0.058 0.521 0.645 0.136
HA r 0.038 0.205 0.426 0.323
p 0.817 0.211 0.007** 0.045*
RD r 0.398 -0.189 -0.007 -0.012
p 0.012* 0.249 0.966 0.942
PS r -0.221 -0.159 -0.263 -0.186
p 0.177 0.334 0.106 0.258
SD r -0.166 -0.222 -0.405 -0.509
p 0.313 0.174 0.011* 0.001***
CO r -0.243 0.019 -0.066 -0.257
p 0.135 0.909 0.690 0.114
ST r 0.187 0.386 0.032 0.411
p 0.254 0.015* 0.847 0.009**
YMRS: Young Mania Rating Scale, HDRS: Hamilton Depression Rating Scale NS: Novelty Seeking, HA: Harm Avoidance, RD: Reward Dependence, PS: Persistence, SD: Self-directedness, CO: Cooperativeness, ST: Self-transcendence, PSS: Perceived Stress Scale, SPS: Suicide Probability Scale.
Table 6. The relationship between suicide attempts and personality dimensions and scale scores in BD patients.
Table 6. The relationship between suicide attempts and personality dimensions and scale scores in BD patients.
Step B Standard Error Wald sd p Exp(B)
1 YMRS -0.379 0.378 1.005 1 0.316 0.684
HDRS 0.952 0.271 12.361 1 0.000*** 2.591
NS -0.004 0.070 0.003 1 0.958 0.996
HA -0.037 0.058 0.399 1 0.528 0.964
RD 0.153 0.129 1.403 1 0.236 1.165
PS 0.017 0.176 0.010 1 0.921 1.018
SD 0.085 0.071 1.459 1 0.227 1.089
CO -0.223 0.097 5.321 1 0.021* 0.800
ST 0.092 0.069 1.773 1 0.183 1.097
PSS 0.092 0.062 2.216 1 0.137 1.097
SPS 0.068 0.067 1.029 1 0.310 1.070
Fixed 1.348 3.562 0.143 1 0.705 3.851
*p<0.05, **p<0.01, ***p<0.001 YMRS: Young Mania Rating Scale, HDRS: Hamilton Depression Rating Scale NS: Novelty Seeking, HA: Harm Avoidance, RD: Reward Dependence, PS: Persistence, SD: Self-directedness, CO: Cooperativeness, ST: Self-transcendence, PSS: Perceived Stress Scale, SPS: Suicide Probability Scale.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
Prerpints.org logo

Preprints.org is a free preprint server supported by MDPI in Basel, Switzerland.

facebook logotwitter logolinkedin logo
MDPI Initiatives
Important Links
Subscribe

Disclaimer

Terms of Use

Privacy Policy

© 2024 MDPI (Basel, Switzerland) unless otherwise stated