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The Influence of High Dose Parenteral Vitamin C Supplementation on Incidence and Severity of Postoperative Pulmonary Complications after Cardiac Surgery with Extracorporeal Circulation: A Prospective, Randomized, Single-Blinded, Interventional Study
Version 1
: Received: 30 January 2024 / Approved: 31 January 2024 / Online: 31 January 2024 (08:56:46 CET)
How to cite:
Kočica, M. K.; Ristić, A.; Soldatović, I.; Lazović, D.; Čumić, J.; Grujić, M.; Karan, R.; Terzić, D.; Palibrk, I.; Kocica, M.; Marković, D. The Influence of High Dose Parenteral Vitamin C Supplementation on Incidence and Severity of Postoperative Pulmonary Complications after Cardiac Surgery with Extracorporeal Circulation: A Prospective, Randomized, Single-Blinded, Interventional Study. Preprints2024, 2024012195. https://doi.org/10.20944/preprints202401.2195.v1
Kočica, M. K.; Ristić, A.; Soldatović, I.; Lazović, D.; Čumić, J.; Grujić, M.; Karan, R.; Terzić, D.; Palibrk, I.; Kocica, M.; Marković, D. The Influence of High Dose Parenteral Vitamin C Supplementation on Incidence and Severity of Postoperative Pulmonary Complications after Cardiac Surgery with Extracorporeal Circulation: A Prospective, Randomized, Single-Blinded, Interventional Study. Preprints 2024, 2024012195. https://doi.org/10.20944/preprints202401.2195.v1
Kočica, M. K.; Ristić, A.; Soldatović, I.; Lazović, D.; Čumić, J.; Grujić, M.; Karan, R.; Terzić, D.; Palibrk, I.; Kocica, M.; Marković, D. The Influence of High Dose Parenteral Vitamin C Supplementation on Incidence and Severity of Postoperative Pulmonary Complications after Cardiac Surgery with Extracorporeal Circulation: A Prospective, Randomized, Single-Blinded, Interventional Study. Preprints2024, 2024012195. https://doi.org/10.20944/preprints202401.2195.v1
APA Style
Kočica, M. K., Ristić, A., Soldatović, I., Lazović, D., Čumić, J., Grujić, M., Karan, R., Terzić, D., Palibrk, I., Kocica, M., & Marković, D. (2024). The Influence of High Dose Parenteral Vitamin C Supplementation on Incidence and Severity of Postoperative Pulmonary Complications after Cardiac Surgery with Extracorporeal Circulation: A Prospective, Randomized, Single-Blinded, Interventional Study. Preprints. https://doi.org/10.20944/preprints202401.2195.v1
Chicago/Turabian Style
Kočica, M. K., Mladen Kocica and Dejan Marković. 2024 "The Influence of High Dose Parenteral Vitamin C Supplementation on Incidence and Severity of Postoperative Pulmonary Complications after Cardiac Surgery with Extracorporeal Circulation: A Prospective, Randomized, Single-Blinded, Interventional Study" Preprints. https://doi.org/10.20944/preprints202401.2195.v1
Abstract
: Cardiac surgery (CS) with extracorporeal circulation (ECC), induces oxidative stress and systemic inflammatory response, which may seriously affect postoperative lung function. We aimed to test if high parenteral (200mg/kg/24h) perioperative (48h) doses of Vitamin C (VitC) may reduce the incidence and severity of postoperative pulmonary complications (PPC) in selected CS patients. Single centered, prospective, randomized, single-blinded, interventional study included 150 patients, assigned to control group A (n=75) and interventional group B (n=75). Group B intraoperatively received 1/4 of the planned daily Vit C dose (200mg/kg/24h), diluted in 10 ml of normal saline, divided into three parts, while Group A received an equal volume of normal saline at the same time frames. After 6 h from the first intraoperative dose, the following regimen was applied: Group B: 200 mg/kg/24h - 30 min i.v. infusion of VitC in 50 ml of normal saline, every 6h, for the next 48h, and Group A: 30 min i.v. infusion of an equal volume of normal saline every 6 hours, for the next 48h. Modified Kroenke’s score was used to determine the incidence and severity of PPC. The overall incidence of PPC was 36.7% and was significantly lower in Group B (13.3% v.s. 60.0%, p<0.001). The severity of PPC was also significantly lower in Group B [1(1) v.s. 3(2), p<0.001]. Besides, patients from Group B had significantly less damaged lungs and better postoperative renal function, shorter ICU stay, fewer ICU re-admissions, and lower hospital mortality. High parenteral daily VitC doses (200mg/kg/24h) given to selected CS patients for 48h after CS are safe and effective in reducing the incidence and severity of PPC. Further multicenter RCT is needed to confirm these results.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.