Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Aptamer-Based Biosensors for Bacterial Detection

Version 1 : Received: 3 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (13:40:14 CET)

How to cite: Léguillier, V.; Heddi, B.; Vidic, J. Aptamer-Based Biosensors for Bacterial Detection. Preprints 2024, 2024020276. https://doi.org/10.20944/preprints202402.0276.v1 Léguillier, V.; Heddi, B.; Vidic, J. Aptamer-Based Biosensors for Bacterial Detection. Preprints 2024, 2024020276. https://doi.org/10.20944/preprints202402.0276.v1

Abstract

The rapid and sensitive detection of pathogenic bacteria is becoming increasingly important for the timely prevention of contamination and treatment of infections. Biosensors based on nucleic acid aptamers integrat-ed with optical, electrochemical, and mass-sensitive analytical techniques have garnered intense interest for their versatility, cost-efficiency, and ability to exhibit high affinity and specificity in binding bacterial bi-omarkers, toxins, and whole cells. This review emphasizes the development of aptamers, their structural op-timization, and their use in bacterial sensing applications. Moreover, we explore barriers and develop per-spectives in applying aptamer-based bacterial detection.

Keywords

Detection; Biosensors; Aptamers; Bacterial pathogens; Food security

Subject

Biology and Life Sciences, Biology and Biotechnology

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