Submitted:
10 March 2024
Posted:
14 March 2024
You are already at the latest version
Abstract
Keywords:
I. Introduction
II. Methods
A. Research Design
B. Agent-Based Modeling (ABM) Simulation
Data Collection
Model Development
C. Simulation Scenarios
D. Model Execution and Sensitivity Analysis
III. Results
A. Simulation Outcomes
| CO2 Concentration Levels | Neurotransmitter Levels |
| 1900 - 1920: 299 ppm 1920 - 1940: 309 ppm 1940 - 1960: 317 ppm |
Glutamate: 2 - 9 μmol/L GABA: 1 - 2 μmol/g Acetylcholine: 90 - 200 ng/mL Dopamine: 30 - 100 pmol/mL Serotonin: 50 - 90 ng/mL |
| CO2 Concentration Levels | Neurotransmitter Levels |
| 1960 - 1980: 330 ppm 1980 - 2000: 389 ppm 2000 - 2020: 412 ppm |
Glutamate: 1 - 6 μmol/L GABA: 0.6 - 0.8 μmol/g Acetylcholine: 50 - 100 ng/mL Dopamine: 20 - 70 pmol/mL Serotonin: 30 - 60 ng/mL |
| CO2 Concentration Levels | Neurotransmitter Levels |
| 2020 - 2040: 450 ppm 2040 - 2060: 590 ppm 2060 - 2080: 710 ppm |
Glutamate: 0.5 - 3 μmol/L GABA: 0.4 - 0.6 μmol/g Acetylcholine: 50 - 70 ng/mL Dopamine: 20 - 30 pmol/mL Serotonin: 20 - 40 ng/mL |
B. Sensitivity Analysis Results
IV. Discussion
V. Conclusion
Acknowledgments
References
- Liu, J.; Baskaran, L.; Bowman, K.; Schimel, D.; Bloom, A.A.; Parazoo, N.C.; Oda, T.; Carroll, D.; Menemenlis, D.; Joiner, J.; et al. Carbon monitoring system flux net biosphere exchange 2020 (CMS-flux NBE 2020). Earth System Science Data 2021, 13, 299–330. [Google Scholar] [CrossRef]
- Satish, U.; Mendell, M.J.; Shekhar, K.; Hotchi, T.; Sullivan, D.; Streufert, S.; Fisk, W.J. Is CO2 an indoor pollutant? Direct effects of low-to-moderate CO2 concentrations on human decision-making performance. Environmental health perspectives 2012, 120, 1671–1677. [Google Scholar] [CrossRef]
- Allen, J.G.; MacNaughton, P.; Satish, U.; Santanam, S.; Vallarino, J.; Spengler, J.D. Associations of cognitive function scores with carbon dioxide, ventilation, and volatile organic compound exposures in office workers: a controlled exposure study of green and conventional office environments. Environmental health perspectives 2016, 124, 805–812. [Google Scholar] [CrossRef] [PubMed]
- Hall, B.D.; Crotwell, A.M.; Kitzis, D.R.; Mefford, T.; Miller, B.R.; Schibig, M.F.; Tans, P.P. Revision of the world meteorological organization global atmosphere watch (WMO/GAW) CO2 calibration scale. Atmospheric Measurement Techniques 2021, 14, 3015–3032. [Google Scholar] [CrossRef]
- Wu, Z.; Lin, D.; Li, Y. Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators. Nature Reviews Neuroscience 2022, 23, 257–274. [Google Scholar] [CrossRef] [PubMed]
- Da, Y.; Luo, S.; Tian, Y. Real-time monitoring of neurotransmitters in the brain of living animals. ACS Applied Materials & Interfaces 2022, 15, 138–157. [Google Scholar] [CrossRef]
- Jiang, Y.; Zou, D.; Li, Y.; Gu, S.; Dong, J.; Ma, X.; Xu, S.; Wang, F.; Huang, J.H. Monoamine neurotransmitters control basic emotions and affect major depressive disorders. Pharmaceuticals 2022, 15, 1203. [Google Scholar] [CrossRef] [PubMed]
- Abrantes, M.; Rodrigues, D.; Domingues, T.; Nemala, S.S.; Monteiro, P.; Borme, J.; Alpuim, P.; Jacinto, L. Ultrasensitive dopamine detection with graphene aptasensor multitransistor arrays. Journal of Nanobiotechnology 2022, 20, 495. [Google Scholar] [CrossRef] [PubMed]
- Billa, S.; Yanamadala, Y.; Hossain, I.; Siddiqui, S.; Moldovan, N.; Murray, T.A.; Arumugam, P.U. Brain-implantable multifunctional probe for simultaneous detection of glutamate and GABA neurotransmitters: optimization and in vivo studies. Micromachines 2022, 13, 1008. [Google Scholar] [CrossRef] [PubMed]
- Wargocki, P.; Wyon, D.P.; Clausen, G.; Fanger, P.O. The effects of outdoor air supply rate in an office on perceived air quality, sick building syndrome (SBS) symptoms and productivity. 2000.


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