Galati, D.; Mallardo, D.; Nicastro, C.; Zanotta, S.; Capitelli, L.; Lombardi, C.; Baino, B.; Cavalcanti, E.; Sale, S.; Labonia, F.; Boenzi, R.; Atripaldi, L.; Ascierto, P.A.; Bocchino, M. The Dysregulation of the Monocyte–Dendritic Cell Interplay Is Associated with In-Hospital Mortality in COVID-19 Pneumonia. J. Clin. Med.2024, 13, 2481.
Galati, D.; Mallardo, D.; Nicastro, C.; Zanotta, S.; Capitelli, L.; Lombardi, C.; Baino, B.; Cavalcanti, E.; Sale, S.; Labonia, F.; Boenzi, R.; Atripaldi, L.; Ascierto, P.A.; Bocchino, M. The Dysregulation of the Monocyte–Dendritic Cell Interplay Is Associated with In-Hospital Mortality in COVID-19 Pneumonia. J. Clin. Med. 2024, 13, 2481.
Galati, D.; Mallardo, D.; Nicastro, C.; Zanotta, S.; Capitelli, L.; Lombardi, C.; Baino, B.; Cavalcanti, E.; Sale, S.; Labonia, F.; Boenzi, R.; Atripaldi, L.; Ascierto, P.A.; Bocchino, M. The Dysregulation of the Monocyte–Dendritic Cell Interplay Is Associated with In-Hospital Mortality in COVID-19 Pneumonia. J. Clin. Med.2024, 13, 2481.
Galati, D.; Mallardo, D.; Nicastro, C.; Zanotta, S.; Capitelli, L.; Lombardi, C.; Baino, B.; Cavalcanti, E.; Sale, S.; Labonia, F.; Boenzi, R.; Atripaldi, L.; Ascierto, P.A.; Bocchino, M. The Dysregulation of the Monocyte–Dendritic Cell Interplay Is Associated with In-Hospital Mortality in COVID-19 Pneumonia. J. Clin. Med. 2024, 13, 2481.
Abstract
Background: The monocyte-phagocyte system (MPS), including monocytes/macrophages and dendritic cells (DCs), plays a key role in anti-viral immunity. We aimed to analyze the prognostic value of the MPS components on in-hospital mortality in a cohort of 58 patients (M/F ; mean ageSD years) with COVID-19 pneumonia and 22 age- and sex-matched healthy controls. Methods: We measured frequencies and absolute numbers of peripheral blood CD169+ monocytes, conventional CD1c+ and CD141+ (namely cDC2 and cDC1), and plasmacytoid CD303+ DCs by means of multi-parametric flow cytometry. A gene profile analysis of 770 immune-inflammatory related human genes and 20 SARS-CoV-2 genes was also performed. Results: Median frequencies and absolute counts of CD169-expressing monocytes were significantly higher in COVID-19 patients than in controls (p 0.04 and p 0.01, respectively). Conversely, percentages and absolute numbers of all DC subsets were markedly depleted in patients (p
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.