PreprintArticleVersion 2This version is not peer-reviewed
Relationship Between Glucose 6-Phosphate Dehydrogenase and Pyruvate Kinase Deficiency With New Generation Inflammation Biomarkers of in Term Newborns With Prolonged Neonatal Jaundice
Version 1
: Received: 26 March 2024 / Approved: 27 March 2024 / Online: 27 March 2024 (08:12:05 CET)
Version 2
: Received: 26 June 2024 / Approved: 27 June 2024 / Online: 27 June 2024 (06:35:55 CEST)
How to cite:
Okuyan, O.; Dumur, S.; Elgormus, Y.; Uzun, H. Relationship Between Glucose 6-Phosphate Dehydrogenase and Pyruvate Kinase Deficiency With New Generation Inflammation Biomarkers of in Term Newborns With Prolonged Neonatal Jaundice. Preprints2024, 2024031649. https://doi.org/10.20944/preprints202403.1649.v2
Okuyan, O.; Dumur, S.; Elgormus, Y.; Uzun, H. Relationship Between Glucose 6-Phosphate Dehydrogenase and Pyruvate Kinase Deficiency With New Generation Inflammation Biomarkers of in Term Newborns With Prolonged Neonatal Jaundice. Preprints 2024, 2024031649. https://doi.org/10.20944/preprints202403.1649.v2
Okuyan, O.; Dumur, S.; Elgormus, Y.; Uzun, H. Relationship Between Glucose 6-Phosphate Dehydrogenase and Pyruvate Kinase Deficiency With New Generation Inflammation Biomarkers of in Term Newborns With Prolonged Neonatal Jaundice. Preprints2024, 2024031649. https://doi.org/10.20944/preprints202403.1649.v2
APA Style
Okuyan, O., Dumur, S., Elgormus, Y., & Uzun, H. (2024). Relationship Between Glucose 6-Phosphate Dehydrogenase and Pyruvate Kinase Deficiency With New Generation Inflammation Biomarkers of in Term Newborns With Prolonged Neonatal Jaundice. Preprints. https://doi.org/10.20944/preprints202403.1649.v2
Chicago/Turabian Style
Okuyan, O., Yusuf Elgormus and Hafize Uzun. 2024 "Relationship Between Glucose 6-Phosphate Dehydrogenase and Pyruvate Kinase Deficiency With New Generation Inflammation Biomarkers of in Term Newborns With Prolonged Neonatal Jaundice" Preprints. https://doi.org/10.20944/preprints202403.1649.v2
Abstract
Aim: To evaluate the clinical findings of glucose 6 phosphate dehydrogenase(G6PD) and pyruvate kinase(PK) deficiency in prolonged jaundice. To determine whether systemic-immune-inflammation index(SII), neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio (PLR) can be used in the diagnosis of neonatal prolonged jaundice. Methods: In full term neonates with hyperbilirubinemia who were admitted to Medicine Hospital between January 2019 and January 2024 with the complaint of jaundice, 167 infants with a serum bilirubin level above 10 mg/dL, whose jaundice persisted after the 10th day, were included in the study. Results: G6PD was negatively correlated with NLR, SII, age, and Hct. There was a negatively poor correlation between G6PD and NLR and a negatively moderate correlation between G6PD and SII when adjusted for age and Hct. PK showed no significant correlation with G6PD, NLR, PLR, SII, age, and Hct. A linear relationship was observed between G6PD and SII and NLR. Conclusions: NLR and SII can be easily calculated in the evaluation of prolonged jaundice in G6PD deficiency has a considerable advantage. NLR and SII levels may contribute by preventing further tests for prolonged jaundice and regulating its treatment. It may be useful to form an opinion in emergencies and in the early period.
Keywords
Prolonged jaundice; breast milk; glucose 6 phosphate dehydrogenase; pyruvate kinase; systemic-immune-inflammation index; neutrophil-to-lymphocyte ratio
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
