Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Antimicrobial and Antifungal Action of Biogenic Silver Nanoparticles in Combination with Antibiotics and Fungicides, against Opportunistic Bacteria and Yeast

Version 1 : Received: 1 May 2024 / Approved: 2 May 2024 / Online: 2 May 2024 (09:46:40 CEST)

How to cite: Rozhin, A.; Batasheva, S.; Iskuzhina, L.; Gomzikova, M.; Kryuchkova, M. Antimicrobial and Antifungal Action of Biogenic Silver Nanoparticles in Combination with Antibiotics and Fungicides, against Opportunistic Bacteria and Yeast. Preprints 2024, 2024050109. https://doi.org/10.20944/preprints202405.0109.v1 Rozhin, A.; Batasheva, S.; Iskuzhina, L.; Gomzikova, M.; Kryuchkova, M. Antimicrobial and Antifungal Action of Biogenic Silver Nanoparticles in Combination with Antibiotics and Fungicides, against Opportunistic Bacteria and Yeast. Preprints 2024, 2024050109. https://doi.org/10.20944/preprints202405.0109.v1

Abstract

The development of multidrug resistance by pathogenic bacteria and yeast is a significant medical problem that needs to be addressed. One possible answer could be the combined use of antibiotics and silver nanoparticles, which have different mechanisms of antimicrobial action. Nanoparticles can be combined with antifungal agents in the same way. Biogenic silver nanoparticles synthesized using environmentally friendly technology using extracts of biologically active plants are an effective nanomaterial that needs to be comprehensively investigated for implementation into medical practice. In this study, the synergistic effects arising from their combined use with antibiotics and fungicides against various bacteria and yeasts, included in the ESKAPE list, were studied. Effective concentrations of substances were established, recommendations for the studied pathogenic species were presented and the effect of destruction of the bacterial membrane was illustrated. The most significant synergistic effect was manifested in pathogenic candida and brewer's yeast.

Keywords

biogenic silver nanoparticles; antibiotic; fungicide; antimicrobial action; antifungal action; Staphylococcus aureus; Escherichia coli; Serratia marcescens; Pseudomonas putida; Alcanivorax borkumensis; Candida albicans; Candida lipolytica; Saccharomyces cerevisiae

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

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