Version 1
: Received: 29 April 2024 / Approved: 7 May 2024 / Online: 7 May 2024 (13:08:33 CEST)
Version 2
: Received: 16 August 2024 / Approved: 19 August 2024 / Online: 20 August 2024 (11:17:36 CEST)
How to cite:
Földes-Papp, Z.; Baumann, G. Single-Molecule Tracking for Live Cell Without Immobilization or Without Hydrodynamic Flow by Simulations: Thermodynamic Jitter. Preprints2024, 2024050395. https://doi.org/10.20944/preprints202405.0395.v2
Földes-Papp, Z.; Baumann, G. Single-Molecule Tracking for Live Cell Without Immobilization or Without Hydrodynamic Flow by Simulations: Thermodynamic Jitter. Preprints 2024, 2024050395. https://doi.org/10.20944/preprints202405.0395.v2
Földes-Papp, Z.; Baumann, G. Single-Molecule Tracking for Live Cell Without Immobilization or Without Hydrodynamic Flow by Simulations: Thermodynamic Jitter. Preprints2024, 2024050395. https://doi.org/10.20944/preprints202405.0395.v2
APA Style
Földes-Papp, Z., & Baumann, G. (2024). Single-Molecule Tracking for Live Cell Without Immobilization or Without Hydrodynamic Flow by Simulations: Thermodynamic Jitter. Preprints. https://doi.org/10.20944/preprints202405.0395.v2
Chicago/Turabian Style
Földes-Papp, Z. and Gerd Baumann. 2024 "Single-Molecule Tracking for Live Cell Without Immobilization or Without Hydrodynamic Flow by Simulations: Thermodynamic Jitter" Preprints. https://doi.org/10.20944/preprints202405.0395.v2
Abstract
Abstract: Experiments to measure a single molecule/particle, i.e. an individual molecule/particle, at room temperature or under physiological conditions without immobilization, for example on a surface, or without significant hydrodynamic flow have so far failed. This failure has given impetus to the underlying theory of Brownian molecular motion towards its stochastics due to diffusion. Quantifying the thermodynamic jitter of molecules/particles inspires many and forms the theoretical basis of single-molecule/single-particle biophysics and biochemistry. For the first time, our simulation results for a live cell (cytoplasm) show that the tracks of individual single molecules are localized in Brownian motion, while there is fanning out in fractal diffusion (anomalous diffusion).
Keywords
individual molecule tracking; individual molecule; single molecule; diffusion; thermodynamic jitter; live cell; cytoplasm; liquids; room temperature; continuous-time random walk (CTRW); Brownian motion; anomalous motion; computer simulation
Subject
Physical Sciences, Biophysics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
