Meyer, N.M.T.; Kabisch, S.; Dambeck, U.; Honsek, C.; Kemper, M.; Gerbracht, C.; Arafat, A.M.; Birkenfeld, A.L.; Schwarz, P.E.H.; Machann, J.; Osterhoff, M.A.; Weickert, M.O.; Pfeiffer, A.F.H. IGF-1 and IGFBP-1 as Possible Predictors of Response to Lifestyle Intervention—Results from Randomized Controlled Trials. Int. J. Mol. Sci.2024, 25, 6400.
Meyer, N.M.T.; Kabisch, S.; Dambeck, U.; Honsek, C.; Kemper, M.; Gerbracht, C.; Arafat, A.M.; Birkenfeld, A.L.; Schwarz, P.E.H.; Machann, J.; Osterhoff, M.A.; Weickert, M.O.; Pfeiffer, A.F.H. IGF-1 and IGFBP-1 as Possible Predictors of Response to Lifestyle Intervention—Results from Randomized Controlled Trials. Int. J. Mol. Sci. 2024, 25, 6400.
Meyer, N.M.T.; Kabisch, S.; Dambeck, U.; Honsek, C.; Kemper, M.; Gerbracht, C.; Arafat, A.M.; Birkenfeld, A.L.; Schwarz, P.E.H.; Machann, J.; Osterhoff, M.A.; Weickert, M.O.; Pfeiffer, A.F.H. IGF-1 and IGFBP-1 as Possible Predictors of Response to Lifestyle Intervention—Results from Randomized Controlled Trials. Int. J. Mol. Sci.2024, 25, 6400.
Meyer, N.M.T.; Kabisch, S.; Dambeck, U.; Honsek, C.; Kemper, M.; Gerbracht, C.; Arafat, A.M.; Birkenfeld, A.L.; Schwarz, P.E.H.; Machann, J.; Osterhoff, M.A.; Weickert, M.O.; Pfeiffer, A.F.H. IGF-1 and IGFBP-1 as Possible Predictors of Response to Lifestyle Intervention—Results from Randomized Controlled Trials. Int. J. Mol. Sci. 2024, 25, 6400.
Abstract
Lifestyle interventions can prevent type 2 diabetes (T2DM). However, some in-dividuals do not experience anticipated improvements despite weight loss. Bi-omarkers to identify such individuals at early stages are lacking. IGF-1 and IGFBP-1 were shown to predict T2DM onset in prediabetes. We assessed if these markers also predict the success of lifestyle interventions, thereby possibly guid-ing personalized strategies.
We analyzed fasting serum levels of IGF-1, IGFBP-1 and IGFBP-2 in relation to changes in metabolic and anthropometric parameters, including intrahepatic li-pids (IHL) and visceral adipose tissue (VAT) volume measured by MRI, in 345 high-risk prediabetic participants (54% female; aged 36-80 years). Participants were enrolled in three randomized dietary intervention trials and assessed both at baseline and one year post-intervention. Statistical analyses were performed using IBM SPSS Statistics (version 28), significance set at p
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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