Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Enhancing the Dispersity and Electrochemical Properties of Chitosan-Coated Carbon Nanotubes for Manufacturing High-Sensitivity Biosensors with Optimal Electrical Conductivity

Version 1 : Received: 8 May 2024 / Approved: 8 May 2024 / Online: 8 May 2024 (15:45:46 CEST)

How to cite: Kim, D. S.; Sobhan, A.; Oh, J.-H.; Lee, J. Enhancing the Dispersity and Electrochemical Properties of Chitosan-Coated Carbon Nanotubes for Manufacturing High-Sensitivity Biosensors with Optimal Electrical Conductivity. Preprints 2024, 2024050519. https://doi.org/10.20944/preprints202405.0519.v1 Kim, D. S.; Sobhan, A.; Oh, J.-H.; Lee, J. Enhancing the Dispersity and Electrochemical Properties of Chitosan-Coated Carbon Nanotubes for Manufacturing High-Sensitivity Biosensors with Optimal Electrical Conductivity. Preprints 2024, 2024050519. https://doi.org/10.20944/preprints202405.0519.v1

Abstract

Recent developments in high-performance electrode materials have been pivotal for real-time monitoring biosensors, necessitating compatibility with biomaterials and robust electrochemi-cal properties. This study explores the development of electrode materials using single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), with a primary fo-cus on assessing their dispersion and electrochemical properties. Various solvents, including N N-Dimethylformamide (DMF), deionized water, ethanol, and acetone, were used for dispersion analysis by employing ultrasonic waves. The results showed that SWCNTs exhibited well-dispersed characteristics without precipitation when introduced to a DMF solution. It found that resistance values decreased as the concentration of SWCNTs increased over the range of 0.025 to 0.4 g/L, with a considerable electrical conductivity reached at concentrations ranging from 0.2 g/L to 0.4 g/L in DMF. The biosensor platform was evaluated with 1-pyrenebutanoic acid succin-imidyl este (PBSE) as the linker and glucose oxidase (Gox) and chitosan as the binding substrate. The binding of Gox with glucose resulted in a significant decrease in resistance value of the biosensor with rising their concentrations ranged from 0.001 to 0.1 M. Though this research provides founda-tional insights for the advancement of SWCNT-based high-performance electrode materials, it will pave the way for the next generation of efficient and reliable biosensors.

Keywords

Dispersity; Biosensor; Single-walled carbon nanotube; Electrical Conductivity; Sensitivity

Subject

Engineering, Bioengineering

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