Review
Version 1
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Mechanisms Underlying the Rarity of Skeletal Muscle Cancers
Version 1
: Received: 7 May 2024 / Approved: 9 May 2024 / Online: 13 May 2024 (04:24:59 CEST)
How to cite: Kump, D. S. Mechanisms Underlying the Rarity of Skeletal Muscle Cancers. Preprints 2024, 2024050608. https://doi.org/10.20944/preprints202405.0608.v1 Kump, D. S. Mechanisms Underlying the Rarity of Skeletal Muscle Cancers. Preprints 2024, 2024050608. https://doi.org/10.20944/preprints202405.0608.v1
Abstract
Skeletal muscle (SKM), despite comprising ~40% of body mass, is rare. This review explores the mechanisms that help to explain this rarity, including unique SKM architecture and function, which prohibits development of new cancer as well as negates potential metastasis to SKM. SKM also presents a unique immune environment that may magnify the anti-tumorigenic effect. Moreover, the SKM microenvironment manifests characteristics such as decreased extracellular matrix stiffness and altered lactic acid, pH, and oxygen levels that may interfere with tumor development. SKM also secretes anti-tumorigenic myokines and other molecules. Collectively, these mechanisms help account for the rarity of SKM cancer.
Keywords
cancer; epidemiology; immune; incidence; metastasis; microenvironment; myokine; prevention; skeletal muscle
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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