Panda, V. K.; Mishra, B.; Nath, A. N.; Butti, R.; Yadav, A. S.; Malhotra, D.; Khanra, S.; Mahapatra, S.; Mishra, P.; Swain, B.; Majhi, S.; Kumari, K.; Radharani, N.; Kundu, G. C. Osteopontin, a Key Multifaceted Regulator in Tumor Progression and Immunomodulation. Preprints2024, 2024050835. https://doi.org/10.20944/preprints202405.0835.v1
APA Style
Panda, V. K., Mishra, B., Nath, A. N., Butti, R., Yadav, A. S., Malhotra, D., Khanra, S., Mahapatra, S., Mishra, P., Swain, B., Majhi, S., Kumari, K., Radharani, N., & Kundu, G. C. (2024). Osteopontin, a Key Multifaceted Regulator in Tumor Progression and Immunomodulation. Preprints. https://doi.org/10.20944/preprints202405.0835.v1
Chicago/Turabian Style
Panda, V. K., NNV Radharani and Gopal C. Kundu. 2024 "Osteopontin, a Key Multifaceted Regulator in Tumor Progression and Immunomodulation" Preprints. https://doi.org/10.20944/preprints202405.0835.v1
Abstract
Tumor microenvironment (TME) is composed of various cellular components such as tumor cells, stromal cells including fibroblasts, adipocytes, mast cell, lymphatic vascular cells and infiltrating immune cells, macrophages, dendritic cells and lymphocytes. The intricate interplay between these cells influences tumor growth, metastasis and therapy failure. Significant advancements in breast cancer therapy have resulted in a substantial decrease in mortality. However, existing cancer treatments frequently result in toxicity and nonspecific side effects. Therefore, improving targeted drug delivery and increasing the efficacy of drugs are crucial for enhancing the treatment outcome and reducing the burden of toxicity. In this review, we provided an overview of how tumor and stroma-derived osteopontin (OPN) plays a key role in regulating the oncogenic potential of various cancers including breast. Next, we have dissected the signalling network by which OPN regulates tumor progression through interaction with selective integrins and CD44 receptors. This review addresses the latest advancement in role of various splice variants of OPN in cancer progression and OPN-mediated tumor-stromal interaction, EMT, CSCs enhancement, immunomodulation, metastasis, chemoresistance, metabolic reprogramming and further suggest that OPN might be a potential therapeutic target and prognostic biomarker for the evolving landscape of cancer management.
Keywords
breast cancer; osteopontin (OPN); tumor associated macrophages; cancer associated fibroblast; immune modulation
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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