PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Early Mediterranean-Based Nutritional Intervention Reduces the Rate of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Post-Hoc Analysis of the San Carlos Gestational Prevention Study
Martín-O’Connor, R.; Ramos-Levi, A.; Melero, V.; Arnoriaga-Rodriguez, M.; Barabash, A.; Valerio, J.; del Valle, L.; de Miguel, P.; Diaz, A.; Familiar, C.; Moraga, I.; Duran, A.; Cuesta, M.; Torrejón, M.J.; Martínez-Novillo, M.; Marcuello, C.; Pazos, M.; Rubio, M.A.; Matía Matin, P.; Calle-Pascual, A.L. Early Mediterranean-Based Nutritional Intervention Reduces the Rate of Gestational Diabetes in Overweight and Obese Pregnant Women: A Post-hoc Analysis of the San Carlos Gestational Prevention Study. Nutrients2024, 16, 2206.
Martín-O’Connor, R.; Ramos-Levi, A.; Melero, V.; Arnoriaga-Rodriguez, M.; Barabash, A.; Valerio, J.; del Valle, L.; de Miguel, P.; Diaz, A.; Familiar, C.; Moraga, I.; Duran, A.; Cuesta, M.; Torrejón, M.J.; Martínez-Novillo, M.; Marcuello, C.; Pazos, M.; Rubio, M.A.; Matía Matin, P.; Calle-Pascual, A.L. Early Mediterranean-Based Nutritional Intervention Reduces the Rate of Gestational Diabetes in Overweight and Obese Pregnant Women: A Post-hoc Analysis of the San Carlos Gestational Prevention Study. Nutrients 2024, 16, 2206.
Martín-O’Connor, R.; Ramos-Levi, A.; Melero, V.; Arnoriaga-Rodriguez, M.; Barabash, A.; Valerio, J.; del Valle, L.; de Miguel, P.; Diaz, A.; Familiar, C.; Moraga, I.; Duran, A.; Cuesta, M.; Torrejón, M.J.; Martínez-Novillo, M.; Marcuello, C.; Pazos, M.; Rubio, M.A.; Matía Matin, P.; Calle-Pascual, A.L. Early Mediterranean-Based Nutritional Intervention Reduces the Rate of Gestational Diabetes in Overweight and Obese Pregnant Women: A Post-hoc Analysis of the San Carlos Gestational Prevention Study. Nutrients2024, 16, 2206.
Martín-O’Connor, R.; Ramos-Levi, A.; Melero, V.; Arnoriaga-Rodriguez, M.; Barabash, A.; Valerio, J.; del Valle, L.; de Miguel, P.; Diaz, A.; Familiar, C.; Moraga, I.; Duran, A.; Cuesta, M.; Torrejón, M.J.; Martínez-Novillo, M.; Marcuello, C.; Pazos, M.; Rubio, M.A.; Matía Matin, P.; Calle-Pascual, A.L. Early Mediterranean-Based Nutritional Intervention Reduces the Rate of Gestational Diabetes in Overweight and Obese Pregnant Women: A Post-hoc Analysis of the San Carlos Gestational Prevention Study. Nutrients 2024, 16, 2206.
Abstract
Obesity is a risk factor for the development of gestational diabetes mellitus (GDM). However, the most optimal type of nutritional intervention to prevent GDM in high-risk women is not clearly defined. This study investigates if nutritional treatment based on the Mediterranean diet (MedDiet) before 12th gestational week (GW) in women at high risk due to a body mass index (BMI)≥25kg/m2, reduces the rate of GDM and metabolic syndrome (MetS) at 3 years postpartum. We performed a post-hoc analysis of the San Carlos Gestational Prevention Study. A total of 735 women with BMI≥25kg/m2 were evaluated between 2015-2018, 246 in standard diet control group (CG) and 489 in MedDiet intervention group (IG). The rate of GDM was significantly lower in IG compared to CG (25.1%vs31.7%;p=0.037). Postnatal follow-up was completed by 141 women in CG (57%) and 312 women in IG (64%). At 3 years postpartum, we observed a reduction (relative risk 95% confidence interval) in the rates of impaired fasting glucose (IFG) (0.51 (0.28-0.92);p=0.019), obesity (0.51 (0.28-0.92),p=0.041), waist circumference (WC)≥89.5cm (0.54 (0.31-0.94);p=0.022) and MetS (0.56 (0.33-0.94);p=0.003). MedDiet reduces the rate of GDM and postpartum MetS in women with BMI)≥25kg/m2, suggesting that its implementation should be routinely recommended from the first GWs.
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
