SARS-CoV-2 Antibody Seroprevalence in Gabon: Findings from the Nationwide Household Serosurvey in a Sub-Saharan Africa Country

Samira Zoa-Assoumou; Paulin Essone; Rafiou Adamou; Sandrine Lydie Oyegue-Liabagui; Amandine Mveang Nzoghe; Bayodé Roméo  Adegbite; Armel Mintsa Ndong; Amel Kévin Alame-Emane; Steeve Hermes Mbomo; Joseph Ndanga Tiagni; Herve Mboyis Kandem; Ayong More; Marien Juliet Verraldy Magossou Mbadinga; Ismael Pierrick Mikelet Boussoukou; Anicet Christel Maloupazoa Siawaya; Juliette Atsame; Aliette Olivia Matsingang; Rodrigue Bikangui; Raphael Edward Ndjonkou Siawaya; Ulrick Leger Davy Mouangala; Davy-Christ Angoune-Ndong; Arnaud Mouhamed Mohod; Anais Malandou; Francis Nziengui-Nziengui; Angelique Ndjoyi-Mbiguino; Franck Mounioko; Lady Charlène Kouna; Cherone Nancy Mbani Mpega Ntigui; Jean Claude Biteghe Bi Esoone; AMALET AKAGHA Armel Brice; Krystina Mengue Me Ngou-Milama; Roméo Karl Imboumy-Limoukou; Magaran Monzon Bagayoko; Inoua Aboubacar; Jean-Bernard Lekana-Douki; Joel Fleury Djoba Siawaya; Ayola Akim Adegnika; Edgard-Brice Ngoungou

doi:10.20944/preprints202405.1763.v1

How to cite: Zoa-Assoumou, S.; Essone, P.; Adamou, R.; Oyegue-Liabagui, S. L.; Mveang Nzoghe, A.; Roméo Adegbite, B.; Mintsa Ndong, A.; Alame-Emane, A. K.; Mbomo, S. H.; Ndanga Tiagni, J.; Mboyis Kandem, H.; More, A.; Magossou Mbadinga, M. J. V.; Mikelet Boussoukou, I. P.; Maloupazoa Siawaya, A. C.; Atsame, J.; Matsingang, A. O.; Bikangui, R.; Ndjonkou Siawaya, R. E.; Mouangala, U. L. D.; Angoune-Ndong, D.-C.; Mouhamed Mohod, A.; Malandou, A.; Nziengui-Nziengui, F.; Ndjoyi-Mbiguino, A.; Mounioko, F.; Kouna, L. C.; Mbani Mpega Ntigui, C. N.; Biteghe Bi Esoone, J. C.; Armel Brice, A. A.; Mengue Me Ngou-Milama, K.; Imboumy-Limoukou, R. K.; Bagayoko, M. M.; Aboubacar, I.; Lekana-Douki, J.-B.; Djoba Siawaya, J. F.; Adegnika, A. A.; Ngoungou, E.-B. SARS-CoV-2 Antibody Seroprevalence in Gabon: Findings from the Nationwide Household Serosurvey in a Sub-Saharan Africa Country. Preprints 2024, 2024051763. https://doi.org/10.20944/preprints202405.1763.v1 Zoa-Assoumou, S.; Essone, P.; Adamou, R.; Oyegue-Liabagui, S. L.; Mveang Nzoghe, A.; Roméo Adegbite, B.; Mintsa Ndong, A.; Alame-Emane, A. K.; Mbomo, S. H.; Ndanga Tiagni, J.; Mboyis Kandem, H.; More, A.; Magossou Mbadinga, M. J. V.; Mikelet Boussoukou, I. P.; Maloupazoa Siawaya, A. C.; Atsame, J.; Matsingang, A. O.; Bikangui, R.; Ndjonkou Siawaya, R. E.; Mouangala, U. L. D.; Angoune-Ndong, D.-C.; Mouhamed Mohod, A.; Malandou, A.; Nziengui-Nziengui, F.; Ndjoyi-Mbiguino, A.; Mounioko, F.; Kouna, L. C.; Mbani Mpega Ntigui, C. N.; Biteghe Bi Esoone, J. C.; Armel Brice, A. A.; Mengue Me Ngou-Milama, K.; Imboumy-Limoukou, R. K.; Bagayoko, M. M.; Aboubacar, I.; Lekana-Douki, J.-B.; Djoba Siawaya, J. F.; Adegnika, A. A.; Ngoungou, E.-B. SARS-CoV-2 Antibody Seroprevalence in Gabon: Findings from the Nationwide Household Serosurvey in a Sub-Saharan Africa Country. Preprints 2024, 2024051763. https://doi.org/10.20944/preprints202405.1763.v1

Abstract

Seroconversion surveys of anti-SARS-CoV-2 antibodies provide accurate estimates of the SARS-CoV-2 infection. This nationwide population-based cross-sectional serosurvey aimed to evaluate the prevalence of SARS-CoV-2 antibodies among residents in Gabon and compare the estimated cumulative number of COVID-19 cases with the officially registered number of laboratory-confirmed cases up to December 2021. Households in each province were randomly selected. Twenty-eight localities including 16 urban and 12 rural, were randomly selected to participate in the study. Whole blood samples were collected in dry tubes from all study participants around the country within 15 days. Serum samples were used to measure the total Immunoglobulin antibodies. Overall, data of 1672 households were analyzed. Out of the 3659 participants, 3175 were found positive for SARS-CoV-2 antibodies, resulting in a crude seroprevalence of 86.77%. Stratification of study participants by age group has shown highest seroprevalences in 20–29 and 40-49 age groups with 91.78% (95% CI:89.5–93.6) and 91.42% (95% CI:88.7–93.5), respectively. Nyanga province had the lowest prevalence (72,8%), and Estuaire and Ogoué-Lolo provinces had the highest prevalence (90 and 92%, respectively). Our results suggest a high transmission rate in the Gabonese population, 21 months after the first SARS-CoV-2 case in the country. This high seroprevalence estimate could indicate that the applied infection control measures may not have been adequately implemented or appropriately adhered to by the population.

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SARS-CoV-2 Antibody Seroprevalence in Gabon: Findings from the Nationwide Household Serosurvey in a Sub-Saharan Africa Country

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