Version 1
: Received: 29 May 2024 / Approved: 29 May 2024 / Online: 30 May 2024 (06:51:48 CEST)
How to cite:
Korobova, Z. R.; Arsentieva, N. A.; Santoni, A.; Totolian, A. A. Role of IL-27 in COVID-19: A Thin Line Between Protection and Disease Promotion. Preprints2024, 2024051973. https://doi.org/10.20944/preprints202405.1973.v1
Korobova, Z. R.; Arsentieva, N. A.; Santoni, A.; Totolian, A. A. Role of IL-27 in COVID-19: A Thin Line Between Protection and Disease Promotion. Preprints 2024, 2024051973. https://doi.org/10.20944/preprints202405.1973.v1
Korobova, Z. R.; Arsentieva, N. A.; Santoni, A.; Totolian, A. A. Role of IL-27 in COVID-19: A Thin Line Between Protection and Disease Promotion. Preprints2024, 2024051973. https://doi.org/10.20944/preprints202405.1973.v1
APA Style
Korobova, Z. R., Arsentieva, N. A., Santoni, A., & Totolian, A. A. (2024). Role of IL-27 in COVID-19: A Thin Line Between Protection and Disease Promotion. Preprints. https://doi.org/10.20944/preprints202405.1973.v1
Chicago/Turabian Style
Korobova, Z. R., Angela Santoni and Areg A. Totolian. 2024 "Role of IL-27 in COVID-19: A Thin Line Between Protection and Disease Promotion" Preprints. https://doi.org/10.20944/preprints202405.1973.v1
Abstract
: Cytokine storm is usually described as one of the main reasons behind COVID-associated mor-tality. Cytokines are essential protein molecules engaged in immune responses; they play a critical role in protection against infections. However, they also contribute to inflammatory reactions and tissue damage, becoming a double-edged sword in the context of COVID-19. Recent studies have suggested various cytokines and chemokines that play a crucial role in the immune response to SARS-CoV-2 infection. One such cytokine is Interleukin 27 (IL-27), which has been found to be elevated in the blood plasma of patients with COVID-19. Within this study, we will explore the role of IL-27 in immune responses and address our own findings concerning this cytokine in COVID-19. It affects a wide variety of immune cells; regardless of the pathological process it is involved in, IL-27 is critical for upholding the necessary balance between tissue damage and cytotoxicity against in-fectious agents and/or tumors. In COVID-19, it is involved in multiple processes, including antiviral cytotoxicity via CD8+ cells, IgG subclass switching, and even the activation of Tregs.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
