Version 1
: Received: 30 May 2024 / Approved: 31 May 2024 / Online: 31 May 2024 (08:51:40 CEST)
How to cite:
Bogusiewicz, J.; Furtak, J.; Birski, M.; Soszyńska, K.; Majdańska, A.; Ryfa, A.; Harat, M.; Bojko, B. Acylcarnitine Profiling in Meningiomas with Different NF2 Mutation Status. Preprints2024, 2024052099. https://doi.org/10.20944/preprints202405.2099.v1
Bogusiewicz, J.; Furtak, J.; Birski, M.; Soszyńska, K.; Majdańska, A.; Ryfa, A.; Harat, M.; Bojko, B. Acylcarnitine Profiling in Meningiomas with Different NF2 Mutation Status. Preprints 2024, 2024052099. https://doi.org/10.20944/preprints202405.2099.v1
Bogusiewicz, J.; Furtak, J.; Birski, M.; Soszyńska, K.; Majdańska, A.; Ryfa, A.; Harat, M.; Bojko, B. Acylcarnitine Profiling in Meningiomas with Different NF2 Mutation Status. Preprints2024, 2024052099. https://doi.org/10.20944/preprints202405.2099.v1
APA Style
Bogusiewicz, J., Furtak, J., Birski, M., Soszyńska, K., Majdańska, A., Ryfa, A., Harat, M., & Bojko, B. (2024). Acylcarnitine Profiling in Meningiomas with Different NF2 Mutation Status. Preprints. https://doi.org/10.20944/preprints202405.2099.v1
Chicago/Turabian Style
Bogusiewicz, J., Marek Harat and Barbara Bojko. 2024 "Acylcarnitine Profiling in Meningiomas with Different NF2 Mutation Status" Preprints. https://doi.org/10.20944/preprints202405.2099.v1
Abstract
The mutation in NF2 is the most common alteration associated with meningioma oncogenesis, and it is related to the loss of a suppressing protein called merlin. At the same time, alterations in energy production are visible in cancer cells where increased demand for energy is observed. Fatty acid oxidation could be one of the ways cancer cells obtain energy. This metabolic pathway uses the acylcarnitine shuttle system, which is responsible for the acylation of fatty acids and their transport through mitochondria. Therefore, this study aimed to profile acylcarnitines with short-, medium- and long-acyl chain length in meningiomas to assess their changes in tumors with different NF2 mutation statuses. For the analysis, solid-phase microextraction (SPME) coupled with liquid chromatography high resolution mass spectrometry (LC-HRMS) was used. The presented sampling method enables low invasive and easy collection of the analytes from the studied lesions, which can be crucial for future analysis of potential biomarkers in the surgery room. It was observed that higher levels of these analytes characterized meningiomas with NF2 mutation. Moreover, increased energy consumption and elevated levels of acylcarnitines show that these analytes can be considered as a marker of increased fatty acid oxidation in NF2 mutated cells.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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