Müller, J.; Boubaker, G.; Müller, N.; Uldry, A.-C.; Braga-Lagache, S.; Heller, M.; Hemphill, A. Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools—Chances and Limitations: A Critical Review. Int. J. Mol. Sci.2024, 25, 6903.
Müller, J.; Boubaker, G.; Müller, N.; Uldry, A.-C.; Braga-Lagache, S.; Heller, M.; Hemphill, A. Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools—Chances and Limitations: A Critical Review. Int. J. Mol. Sci. 2024, 25, 6903.
Müller, J.; Boubaker, G.; Müller, N.; Uldry, A.-C.; Braga-Lagache, S.; Heller, M.; Hemphill, A. Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools—Chances and Limitations: A Critical Review. Int. J. Mol. Sci.2024, 25, 6903.
Müller, J.; Boubaker, G.; Müller, N.; Uldry, A.-C.; Braga-Lagache, S.; Heller, M.; Hemphill, A. Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools—Chances and Limitations: A Critical Review. Int. J. Mol. Sci. 2024, 25, 6903.
Abstract
Identification of drug targets and biochemical investigations on mechanisms of action is a are major issues in modern drug development. The present article reviews the classical “one drug” – “one target” paradigm. Novel methods for target deconvolution and for investigation of resistant strains based on protein mass spectrometry have shown that multiple gene products and adapta-tion mechanisms are involved in responses of pathogens to xenobiotics. This review is focused on protozoan pathogens. The conclusions can, however, be extended to chemotherapies against other pathogens or cancer. For this review we have searched Pubmed (pubmed.ncbi.nlm.nih.gov) and Web of Science (webofscience.com) using the key words listed below (status May 2024)
Keywords
Adaptation; mass spectrometry; model system; mode of action; resistance; target
Subject
Biology and Life Sciences, Parasitology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
,
,
,
