PreprintCase ReportVersion 1Preserved in Portico This version is not peer-reviewed
Adult-Onset Systemic Chronic Active Epstein - Barr virus Disease: A Case Report Highlighting Unique Immunophenotype and Novel Molecular Insights in the Context of Chronic HBV Hepatitis
Version 1
: Received: 30 May 2024 / Approved: 31 May 2024 / Online: 3 June 2024 (07:58:45 CEST)
How to cite:
Geevar, T.; Sabatini, P. J.; Zhang, T.; Sakhdari, A. Adult-Onset Systemic Chronic Active Epstein - Barr virus Disease: A Case Report Highlighting Unique Immunophenotype and Novel Molecular Insights in the Context of Chronic HBV Hepatitis. Preprints2024, 2024052167. https://doi.org/10.20944/preprints202405.2167.v1
Geevar, T.; Sabatini, P. J.; Zhang, T.; Sakhdari, A. Adult-Onset Systemic Chronic Active Epstein - Barr virus Disease: A Case Report Highlighting Unique Immunophenotype and Novel Molecular Insights in the Context of Chronic HBV Hepatitis. Preprints 2024, 2024052167. https://doi.org/10.20944/preprints202405.2167.v1
Geevar, T.; Sabatini, P. J.; Zhang, T.; Sakhdari, A. Adult-Onset Systemic Chronic Active Epstein - Barr virus Disease: A Case Report Highlighting Unique Immunophenotype and Novel Molecular Insights in the Context of Chronic HBV Hepatitis. Preprints2024, 2024052167. https://doi.org/10.20944/preprints202405.2167.v1
APA Style
Geevar, T., Sabatini, P. J., Zhang, T., & Sakhdari, A. (2024). Adult-Onset Systemic Chronic Active Epstein - Barr virus Disease: A Case Report Highlighting Unique Immunophenotype and Novel Molecular Insights in the Context of Chronic HBV Hepatitis. Preprints. https://doi.org/10.20944/preprints202405.2167.v1
Chicago/Turabian Style
Geevar, T., Tong Zhang and Ali Sakhdari. 2024 "Adult-Onset Systemic Chronic Active Epstein - Barr virus Disease: A Case Report Highlighting Unique Immunophenotype and Novel Molecular Insights in the Context of Chronic HBV Hepatitis" Preprints. https://doi.org/10.20944/preprints202405.2167.v1
Abstract
We present a case of adult-onset systemic chronic active EBV disease (CAEBV) in a 40-year-old woman with chronic HBV hepatitis. Initial symptoms resembled a viral illness, progressing to recurrent fever, transaminitis, and anasarca. Investigations revealed high-level EBV viremia and an abnormal T-cell population in liver and bone marrow, indicative of CAEBV. Liver biopsy showed CD3+ T-cells lacking TCRbeta and displaying dim/negative CD5, with elevated EBV-infected T-cells. Next-generation sequencing identified rare variants in CREBBP, SPEN, TP73, and PLCG2, suggesting potential contributions to disease pathogenesis. This case underscores diagnostic challenges and management complexities of adult-onset CAEBV, particularly with underlying chronic HBV infection. Genomic profiling offers crucial insights into the molecular landscape of rare lymphoid malignancies, highlighting the importance of personalized treatment strategies. The distinct immunophenotypic features underscore the heterogeneity in EBV-associated T-cell LPDs, urging further research for optimized clinical management
Keywords
chronic EBV infection; T cell lymphoproliferative disorder; mutational profile
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
