Lukyanov, S.A.; Titov, S.E.; Kozorezova, E.S.; Demenkov, P.S.; Veryaskina, Y.A.; Korotovskii, D.V.; Ilyina, T.E.; Vorobyev, S.L.; Zhivotov, V.A.; Bondarev, N.S.; Sleptsov, I.V.; Sergiyko, S.V. Prediction of the Aggressive Clinical Course of Papillary Thyroid Carcinoma Based on Fine Needle Aspiration Biopsy Molecular Testing. Int. J. Mol. Sci.2024, 25, 7090.
Lukyanov, S.A.; Titov, S.E.; Kozorezova, E.S.; Demenkov, P.S.; Veryaskina, Y.A.; Korotovskii, D.V.; Ilyina, T.E.; Vorobyev, S.L.; Zhivotov, V.A.; Bondarev, N.S.; Sleptsov, I.V.; Sergiyko, S.V. Prediction of the Aggressive Clinical Course of Papillary Thyroid Carcinoma Based on Fine Needle Aspiration Biopsy Molecular Testing. Int. J. Mol. Sci. 2024, 25, 7090.
Lukyanov, S.A.; Titov, S.E.; Kozorezova, E.S.; Demenkov, P.S.; Veryaskina, Y.A.; Korotovskii, D.V.; Ilyina, T.E.; Vorobyev, S.L.; Zhivotov, V.A.; Bondarev, N.S.; Sleptsov, I.V.; Sergiyko, S.V. Prediction of the Aggressive Clinical Course of Papillary Thyroid Carcinoma Based on Fine Needle Aspiration Biopsy Molecular Testing. Int. J. Mol. Sci.2024, 25, 7090.
Lukyanov, S.A.; Titov, S.E.; Kozorezova, E.S.; Demenkov, P.S.; Veryaskina, Y.A.; Korotovskii, D.V.; Ilyina, T.E.; Vorobyev, S.L.; Zhivotov, V.A.; Bondarev, N.S.; Sleptsov, I.V.; Sergiyko, S.V. Prediction of the Aggressive Clinical Course of Papillary Thyroid Carcinoma Based on Fine Needle Aspiration Biopsy Molecular Testing. Int. J. Mol. Sci. 2024, 25, 7090.
Abstract
Background: Molecular genetic events are among the numerous factors affecting the clinical course of papillary thyroid carcinoma (PTC). Recent studies have demonstrated that aberrant expression of miRNA, as well as different thyroid-related genes, correlate with the aggressive clinical course of PTC and unfavorable treatment outcome, which opens up new avenues for using them in personalization of the treatment strategy for patients with PTC. In the present work, our goal was to assess the applicability of molecular markers in preoperative diagnosis of aggressive variants of papillary thyroid cancer. Methods: The molecular genetic profile (expression levels of 34 different markers and BRAF mutation) was studied for 108 cytology specimens collected by fine-needle aspiration biopsy in patients with PTC having different clinical manifestations. Results: Statistically significant differences with adjustment for multiple comparisons (p < 0.0015) for clinically aggressive variants of PTC were obtained for four markers: miRNA-146b, miRNA-221, FN1, and CDKN2A. Weak statistical correlation (0.0015< р<0.05) was observed for miRNA-31, -375, -551b, -148b, -125b, mtDNA, CITED1, TPO, HMGA2, CLU, NIS, SERPINA1, TFF3, and TMPRSS4. Conclusions: The recurrence risk of papillary thyroid carcinoma can be preoperatively predicted using miRNA-221, the fibronectin and cyclin-dependent kinase inhibitor 2A genes.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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