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A Novel Method for the Preparation of Casein-Fucoidan Compo-Site Nanostructures
Version 1
: Received: 4 June 2024 / Approved: 5 June 2024 / Online: 5 June 2024 (14:56:43 CEST)
A peer-reviewed article of this Preprint also exists.
Zahariev, N.; Pilicheva, B. A Novel Method for the Preparation of Casein–Fucoidan Composite Nanostructures. Polymers 2024, 16, 1818. Zahariev, N.; Pilicheva, B. A Novel Method for the Preparation of Casein–Fucoidan Composite Nanostructures. Polymers 2024, 16, 1818.
Abstract
The aim of the study was to develop casein-fucoidan composite nanostructures through the method of polyelectrolyte complexation and subsequent spray drying. To determine the optimal parameters for the preparation of the composite structures and to investigate the influence of the production and technological parameters on the main structural and morphological characteristics of the obtained structures, 3(k-p) fractional factorial design was applied. The independent variables (casein to fucoidan ration, glutaraldehyde concentration and spray intensity) were varied at three levels (low, medium, and high) and their effect on the yield, the average particle size and the zeta potential were evaluated statistically. Based on the obtained results, models C1F1G1Sp.30, C1F1G2Sp.40, and C1F1G3Sp.50, which have an average particle size ranging from (265 ± 32) nm to (357 ± 25) nm, production yield in the range (48.9 ± 2.9) % to (66.4 ± 2.2) % and zeta potential varying from ( −20.12 ± 0.9) mV to (−25.71 ± 1.0) mV were selected as optimal for further use as drug delivery systems.
Keywords
casein; fucoidan; polyelectrolyte complexation; spray drying; experimental design; nanocomposites
Subject
Medicine and Pharmacology, Pharmacy
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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