PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Hydrogen and Methane Production in Response to Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Levels in Patients with Type 2 Diabetes and Normoglycemic Subjects
Version 1
: Received: 5 June 2024 / Approved: 6 June 2024 / Online: 6 June 2024 (12:49:56 CEST)
How to cite:
Misnikova, I. V.; Kovaleva, Y. A.; Shokur, S. Y.; LeBaron, T. W.; Povarova, O. V.; Medvedev, O. S. Hydrogen and Methane Production in Response to Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Levels in Patients with Type 2 Diabetes and Normoglycemic Subjects. Preprints2024, 2024060385. https://doi.org/10.20944/preprints202406.0385.v1
Misnikova, I. V.; Kovaleva, Y. A.; Shokur, S. Y.; LeBaron, T. W.; Povarova, O. V.; Medvedev, O. S. Hydrogen and Methane Production in Response to Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Levels in Patients with Type 2 Diabetes and Normoglycemic Subjects. Preprints 2024, 2024060385. https://doi.org/10.20944/preprints202406.0385.v1
Misnikova, I. V.; Kovaleva, Y. A.; Shokur, S. Y.; LeBaron, T. W.; Povarova, O. V.; Medvedev, O. S. Hydrogen and Methane Production in Response to Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Levels in Patients with Type 2 Diabetes and Normoglycemic Subjects. Preprints2024, 2024060385. https://doi.org/10.20944/preprints202406.0385.v1
APA Style
Misnikova, I. V., Kovaleva, Y. A., Shokur, S. Y., LeBaron, T. W., Povarova, O. V., & Medvedev, O. S. (2024). Hydrogen and Methane Production in Response to Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Levels in Patients with Type 2 Diabetes and Normoglycemic Subjects. Preprints. https://doi.org/10.20944/preprints202406.0385.v1
Chicago/Turabian Style
Misnikova, I. V., Oxana Viktorovna Povarova and Oleg S. Medvedev. 2024 "Hydrogen and Methane Production in Response to Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Levels in Patients with Type 2 Diabetes and Normoglycemic Subjects" Preprints. https://doi.org/10.20944/preprints202406.0385.v1
Abstract
The aim of this study was to investigate the relationship between postprandial glycemic levels based on flash-monitoring and the production of intestinal hydrogen (H2) and methane (CH4) gases based on measurement of the amount of these gases in exhaled air. We studied 14 subjects with type 2 diabetes mellitus (T2DM) and 10 individuals without diabetes (control) with 3 food-load tests with simultaneous determination of gases in exhaled air and assessment of glucose levels. In 15.4% of patients with T2DM, there was a non-significant increase in exhaled H2. How-ever, all subjects in the control group had significant increase in exhaled H2. Moreover, the level of H2 in exhaled breathafter food load in patients with T2DM was lower than in normoglycemic subjects. Also, in normoglycemic subjects there was an inverse correlation between maximum glucose rise and maximum H2 in exhaled air after food load. At the same time in patients with T2DM the level of CH4 in exhaled air directly correlated with the parameters of postprandial glycemia in the test with lactulose. Confirmation of a causal relationship between decreased H2 production, increased intestinal CH4 production, and more severe postprandial glycemia may identify new therapeutic targets in the correction of postprandial glycemia in patients with T2DM.
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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