Identification and Molecular Characterization of the Human GcMAF Receptor

Marco Ruggiero

doi:10.20944/preprints202406.0455.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 7 June 2024 / Approved: 7 June 2024 / Online: 7 June 2024 (08:25:12 CEST)
Version 2 : Received: 21 June 2024 / Approved: 21 June 2024 / Online: 21 June 2024 (08:11:03 CEST)

This study proposes the first extracellular domain (residues 1-34) of the CCR1 protein as the Gc protein-derived Macrophage Activating Factor (GcMAF) receptor. The CCR1 gene, expressed in monocytes and 168 other cell types or tissues, encodes this transmembrane protein. Electrostatic and hydrophobic interactions, along with hydrogen bonds mediate the molecular interactions between the TPT⁴²⁰^-^GalNAcELAK (or TPK⁴²⁰ELAK) sequences of GcMAF (or Gc2 protein variant) and the TTEDYDTTT sequence of its receptor.

GcMAF; receptor; immune system; cancer; autism; COVID-19

Medicine and Pharmacology, Immunology and Allergy

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Identification and Molecular Characterization of the Human GcMAF Receptor

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