Version 1
: Received: 7 June 2024 / Approved: 7 June 2024 / Online: 7 June 2024 (10:21:06 CEST)
How to cite:
Tong, J. G.; Li, H.; Shen, Y.; Tan, Z.; Qian, H. The Combined Evaluation of Preoperative Serum CEA and Postoperative Tissue CEA as One Factor on the Prognosis of 0~ⅣColorectal Cancer. Preprints2024, 2024060482. https://doi.org/10.20944/preprints202406.0482.v1
Tong, J. G.; Li, H.; Shen, Y.; Tan, Z.; Qian, H. The Combined Evaluation of Preoperative Serum CEA and Postoperative Tissue CEA as One Factor on the Prognosis of 0~ⅣColorectal Cancer. Preprints 2024, 2024060482. https://doi.org/10.20944/preprints202406.0482.v1
Tong, J. G.; Li, H.; Shen, Y.; Tan, Z.; Qian, H. The Combined Evaluation of Preoperative Serum CEA and Postoperative Tissue CEA as One Factor on the Prognosis of 0~ⅣColorectal Cancer. Preprints2024, 2024060482. https://doi.org/10.20944/preprints202406.0482.v1
APA Style
Tong, J. G., Li, H., Shen, Y., Tan, Z., & Qian, H. (2024). The Combined Evaluation of Preoperative Serum CEA and Postoperative Tissue CEA as One Factor on the Prognosis of 0~ⅣColorectal Cancer. Preprints. https://doi.org/10.20944/preprints202406.0482.v1
Chicago/Turabian Style
Tong, J. G., Zhenhua Tan and Hai Qian. 2024 "The Combined Evaluation of Preoperative Serum CEA and Postoperative Tissue CEA as One Factor on the Prognosis of 0~ⅣColorectal Cancer" Preprints. https://doi.org/10.20944/preprints202406.0482.v1
Abstract
Background: The role of preoperative serum carcinoembryonic antigen (sCEA) and postopeative tissue CEA (tCEA ) were widely elaborated separately for colorectal cancer (CRC). But the role of the combined sCEA and tCEA was scarcely described by now. Methods: 1757 cases of 0~ⅣCRC from January 2006 to January 2016 in our institution were involved. Clinicopathological features and follow up data were collected. 0 stage was combined into 0&Ⅰ stages. SCEA was classified to normal and high(>10ng/ml) and tCEA were classified into three grades (+,++,+++). So combined groups were six (2ⅹ3). ANOVA and Crosstab were used to analyze continuous and counting data, Univariate and multivariate were analyzed by Cox regression. All data were analyzed by SPSS27 and survival curves with number at risk were visualized by R 4.3.1. Results: Gender, age, tumor location, tumor size, blood loss, T stage, differentiation, harvested lymph nodes, positive lymph nodes, chemotherapy, TNM stage and complication have difference between the combined CEA test (all P
Keywords
CRC; Prognosis; sCEA; tCEA ; combined CEA; ROC; AUC; OS
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
