Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Phytocompounds Targeting for the Treatment of β-Thalassemia: A Review

Version 1 : Received: 8 June 2024 / Approved: 10 June 2024 / Online: 11 June 2024 (08:59:21 CEST)

A peer-reviewed article of this Preprint also exists.

Swapnadeep Ghosh, Moutusi Mandi, Phytocompounds Targeting For The Treatment Of β -Thalassemia: A Review, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 6, 768-786. https://doi.org/10.5281/zenodo.11654790 Swapnadeep Ghosh, Moutusi Mandi, Phytocompounds Targeting For The Treatment Of β -Thalassemia: A Review, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 6, 768-786. https://doi.org/10.5281/zenodo.11654790

Abstract

For treating β-thalassemia, increasing foetal haemoglobin (HbF) production with drugs shows promising result. Many studies have focused on finding new HbF-inducing phytocompounds and understanding how they work. This review compiles the identified agents so far. While these agents can stimulate HbF production, chemotherapy drugs cannot be practically used for treating β-haemoglobinopathies, like β-thalassemia, due to their toxicity and growth-inhibiting effects. To overcome this issue, researchers are exploring natural plant sources for effective, safe, and easy-to-use HbF-inducing agents. This review highlights summarizes the natural phytocompounds that stimulate HbF production, aiming to provide new insights into future treatments for β-thalassemia.

Keywords

β-thalassemia; foetal haemoglobin (HbF); β-haemoglobinopathies; chemotherapy drugs; phytocompounds

Subject

Biology and Life Sciences, Plant Sciences

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