PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Comparative Analysis of p16 and p53 Expression Rates Ac-cording to Positivity of Human Papillomavirus in Head and Neck Cutaneous Squamous Cell Carcinoma
Version 1
: Received: 10 June 2024 / Approved: 11 June 2024 / Online: 12 June 2024 (08:14:15 CEST)
How to cite:
Nam, H. J.; Ryu, H. R.; Lee, D. W.; Byeon, J. Y.; Kim, J. H.; Lee, J.-H.; Lim, S.; Choi, H. J. Comparative Analysis of p16 and p53 Expression Rates Ac-cording to Positivity of Human Papillomavirus in Head and Neck Cutaneous Squamous Cell Carcinoma. Preprints2024, 2024060751. https://doi.org/10.20944/preprints202406.0751.v1
Nam, H. J.; Ryu, H. R.; Lee, D. W.; Byeon, J. Y.; Kim, J. H.; Lee, J.-H.; Lim, S.; Choi, H. J. Comparative Analysis of p16 and p53 Expression Rates Ac-cording to Positivity of Human Papillomavirus in Head and Neck Cutaneous Squamous Cell Carcinoma. Preprints 2024, 2024060751. https://doi.org/10.20944/preprints202406.0751.v1
Nam, H. J.; Ryu, H. R.; Lee, D. W.; Byeon, J. Y.; Kim, J. H.; Lee, J.-H.; Lim, S.; Choi, H. J. Comparative Analysis of p16 and p53 Expression Rates Ac-cording to Positivity of Human Papillomavirus in Head and Neck Cutaneous Squamous Cell Carcinoma. Preprints2024, 2024060751. https://doi.org/10.20944/preprints202406.0751.v1
APA Style
Nam, H. J., Ryu, H. R., Lee, D. W., Byeon, J. Y., Kim, J. H., Lee, J. H., Lim, S., & Choi, H. J. (2024). Comparative Analysis of p16 and p53 Expression Rates Ac-cording to Positivity of Human Papillomavirus in Head and Neck Cutaneous Squamous Cell Carcinoma. Preprints. https://doi.org/10.20944/preprints202406.0751.v1
Chicago/Turabian Style
Nam, H. J., Soomin Lim and Hwan Jun Choi. 2024 "Comparative Analysis of p16 and p53 Expression Rates Ac-cording to Positivity of Human Papillomavirus in Head and Neck Cutaneous Squamous Cell Carcinoma" Preprints. https://doi.org/10.20944/preprints202406.0751.v1
Abstract
The high prevalence of human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) is well-established, with p16 expression being a strong predictor. HPV-related tumors exhibit unique mechanisms targeting p16 and p53 proteins. However, re-search on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous squamous cell carcinomas (HNCSCC), especially in Asian populations, is limited. This retrospective study surveyed 62 HNCSCC patients (2011–2020), excluding those with facial warts or other skin cancers. All patients underwent wide excision and biopsy. Immuno-histochemical staining for HPV, p16, and p53 yielded both positive and negative results. The relevance of each marker was investigated by categorizing the tumor locations into high-risk (Area H) and mid-risk (Area M) zones based on recurrence frequency. Of the 62 patients, 20 (32.26%) were male, with an average age of 82.27 years (26–103). Area H included 19 cases (30.65%), with the eyelid and lip being the most common sites (five cases, 8.06%). Area M in-cluded 43 cases (69.35%), with the cheek being the most common site (29 cases, 46.77%). p16 ex-pression was positive in 24 patients (38.71%), p53 expression in 42 patients (72.58%), and HPV in five patients (8.06%). No significant association was found between p16 expression and HPV presence (p > 0.99), with a positive predictive value of 8.33%. This indicates that p16, a surrogate marker of HPV in OPSCC, is not a reliable marker for HPV in HNCSCC. This study enhances our understanding of the relationship between HPV, p53, and p16 in HNCSCC in Asian populations and offers valuable insights for further research.
Keywords
squamous cell carcinoma; oropharyngeal; non-oropharyngeal; human papillomavirus; p16; p53
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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