Version 1
: Received: 11 June 2024 / Approved: 11 June 2024 / Online: 11 June 2024 (22:37:22 CEST)
How to cite:
Kim, E.; Park, Y.; Yun, M.; Kim, B. Preventive Functions of Hemp-Derived Biomaterials Against Periodontal Deterioration Caused by Fine Dust. Preprints2024, 2024060752. https://doi.org/10.20944/preprints202406.0752.v1
Kim, E.; Park, Y.; Yun, M.; Kim, B. Preventive Functions of Hemp-Derived Biomaterials Against Periodontal Deterioration Caused by Fine Dust. Preprints 2024, 2024060752. https://doi.org/10.20944/preprints202406.0752.v1
Kim, E.; Park, Y.; Yun, M.; Kim, B. Preventive Functions of Hemp-Derived Biomaterials Against Periodontal Deterioration Caused by Fine Dust. Preprints2024, 2024060752. https://doi.org/10.20944/preprints202406.0752.v1
APA Style
Kim, E., Park, Y., Yun, M., & Kim, B. (2024). Preventive Functions of Hemp-Derived Biomaterials Against Periodontal Deterioration Caused by Fine Dust. Preprints. https://doi.org/10.20944/preprints202406.0752.v1
Chicago/Turabian Style
Kim, E., Mihae Yun and Boyong Kim. 2024 "Preventive Functions of Hemp-Derived Biomaterials Against Periodontal Deterioration Caused by Fine Dust" Preprints. https://doi.org/10.20944/preprints202406.0752.v1
Abstract
Although fine dust can cause various disorders, including cardiovascular, neurological, renal, reproductive, motor, systemic, respiratory, and cancerous diseases, there are not enough research for an oral disease. In this study we used various methods, including quantitative PCR, flow cytometry, immunocytochemistry, ELISA, and Alizarin O staining, to reveal the preventive effects of hemp-derived biomaterials in periodontal cells against fine dust. In this study, the two biomaterials (MSE; mature hemp stem extract and IE; induced exosomes derived from gingival cells exposed to MSE) revealed three main biological functions against fine dust. First, two materials suppressed the levels of inflammatory genes and activated anti-inflammatory genes in gingival cells. Second, these materials activated differentiation to osteoblast, periodontal ligament cells (PDLCs) and pulp progenitor cells (PPCs) from periodontal ligament stem cells (PDLSCs). Third, IE and MSE activated upregulation of LL-37 and down-regulation of MCP-1 in gingival cells and PDLSCs, respectively. Consequently, MSE and IE showed potential as a functional biomaterial in various fields, including pharmaceuticals, cosmetics, and foods.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
