PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Pharmaco-Epidemiological Study and Correlation between Antibiotic Resistance and Antibiotic Consumption in a Tunisian Teaching Hospital from 2010 to 2022
Version 1
: Received: 11 June 2024 / Approved: 11 June 2024 / Online: 12 June 2024 (14:12:12 CEST)
How to cite:
Kasbi, Y.; Sellami, F.; Ferjani, A.; Abbassi, A.; Boutiba Ben Boubaker, I. Pharmaco-Epidemiological Study and Correlation between Antibiotic Resistance and Antibiotic Consumption in a Tunisian Teaching Hospital from 2010 to 2022. Preprints2024, 2024060786. https://doi.org/10.20944/preprints202406.0786.v1
Kasbi, Y.; Sellami, F.; Ferjani, A.; Abbassi, A.; Boutiba Ben Boubaker, I. Pharmaco-Epidemiological Study and Correlation between Antibiotic Resistance and Antibiotic Consumption in a Tunisian Teaching Hospital from 2010 to 2022. Preprints 2024, 2024060786. https://doi.org/10.20944/preprints202406.0786.v1
Kasbi, Y.; Sellami, F.; Ferjani, A.; Abbassi, A.; Boutiba Ben Boubaker, I. Pharmaco-Epidemiological Study and Correlation between Antibiotic Resistance and Antibiotic Consumption in a Tunisian Teaching Hospital from 2010 to 2022. Preprints2024, 2024060786. https://doi.org/10.20944/preprints202406.0786.v1
APA Style
Kasbi, Y., Sellami, F., Ferjani, A., Abbassi, A., & Boutiba Ben Boubaker, I. (2024). Pharmaco-Epidemiological Study and Correlation between Antibiotic Resistance and Antibiotic Consumption in a Tunisian Teaching Hospital from 2010 to 2022. Preprints. https://doi.org/10.20944/preprints202406.0786.v1
Chicago/Turabian Style
Kasbi, Y., Aimen Abbassi and Ilhem Boutiba Ben Boubaker. 2024 "Pharmaco-Epidemiological Study and Correlation between Antibiotic Resistance and Antibiotic Consumption in a Tunisian Teaching Hospital from 2010 to 2022" Preprints. https://doi.org/10.20944/preprints202406.0786.v1
Abstract
The exponential rise of bacterial resistance poses a threat to antibiotic efficacy, with a great impact on public health. This study aims to analyze the correlation between antibiotic consumption and the emergence of bacterial resistance. Conducted retrospectively at Charles Nicolle Hospital in Tunis, Tunisia from 2010 to 2022, this study was based on STKMED® software for antibiotic consumption data, hospital administrative records for the number of hospitalization days, and SIRSCAN® software for bacteriological data. Data processing was performed using Excel® software, and analysis was conducted using SPSS23®. In 2022, Consumption was almost evenly split between the two major “AWaRe” groups, with 49.33% for "Access" and 46.89% for "Watch", and the consumption of the "Reserve" group also increased, accounting for 3.77% of the total. Bacterial resistances, notably carbapenem-resistant Klebsiella pneumoniae, increased. Seventy-four significant correlations were identified, including those be-tween carbapenem consumption and resistance in Escherichia coli and Klebsiella pneumoniae strains. However, no significant corre-lation was observed with imipenem-resistant Pseudomonas aeruginosa strains. The significant correlations between the emergence of bacterial resistance and antibiotic use, particularly with antibiotics in the "Watch" and "Reserve" groups, underscore the urgent need to continue efforts to combat this threat through rational antibiotic use.
Keywords
Tunisian hospital; antibiotics; antimicrobial resistance; AWaRe classification; correlation; Consumption
Subject
Medicine and Pharmacology, Pharmacy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
