Version 1
: Received: 11 June 2024 / Approved: 12 June 2024 / Online: 12 June 2024 (14:58:26 CEST)
How to cite:
Sugino, K. Y.; Hernandez, T. L.; Barbour, L. A.; Kofonow, J. M.; Frank, D. N.; Friedman, A. J. E. Distinct Plasma Metabolomic and Gut Microbiome Profiles After GDM Diet Treatment: Implications for Personalized Dietary Interventions. Preprints2024, 2024060803. https://doi.org/10.20944/preprints202406.0803.v1
Sugino, K. Y.; Hernandez, T. L.; Barbour, L. A.; Kofonow, J. M.; Frank, D. N.; Friedman, A. J. E. Distinct Plasma Metabolomic and Gut Microbiome Profiles After GDM Diet Treatment: Implications for Personalized Dietary Interventions. Preprints 2024, 2024060803. https://doi.org/10.20944/preprints202406.0803.v1
Sugino, K. Y.; Hernandez, T. L.; Barbour, L. A.; Kofonow, J. M.; Frank, D. N.; Friedman, A. J. E. Distinct Plasma Metabolomic and Gut Microbiome Profiles After GDM Diet Treatment: Implications for Personalized Dietary Interventions. Preprints2024, 2024060803. https://doi.org/10.20944/preprints202406.0803.v1
APA Style
Sugino, K. Y., Hernandez, T. L., Barbour, L. A., Kofonow, J. M., Frank, D. N., & Friedman, A. J. E. (2024). Distinct Plasma Metabolomic and Gut Microbiome Profiles After GDM Diet Treatment: Implications for Personalized Dietary Interventions. Preprints. https://doi.org/10.20944/preprints202406.0803.v1
Chicago/Turabian Style
Sugino, K. Y., Daniel N. Frank and and Jacob E. Friedman. 2024 "Distinct Plasma Metabolomic and Gut Microbiome Profiles After GDM Diet Treatment: Implications for Personalized Dietary Interventions" Preprints. https://doi.org/10.20944/preprints202406.0803.v1
Abstract
Gestational diabetes mellitus (GDM) triggers alterations in the maternal gut microbiome. Alongside metabolic shifts, microbial products may impact clinical factors and influence pregnancy outcomes. Here, we performed two separate analyses to integrate the maternal microbiome-metabolomic differences from a subset of the “Choosing Healthy Options in Carbohydrate Energy” (CHOICE) study. Women diagnosed with GDM were randomized to a diet higher in complex carbohydrates (CHOICE, n=18, 60% complex carbohydrate/25% fat/15% protein) or a conventional GDM diet (CONV, n=16, 40% carbohydrate/45% fat/15% protein). All meals were provided, diets were eucaloric, and fiber content was similar. CHOICE diet was associated with increases in TMAO, lysophosphotidylcholines, indoxyl sulfate, and several triglyceride (TG) species, while CONV diet was associated with higher plasma hippuric acid, aspartic acid, betaine, glutamic acid, indole propionic acid, and indoleacetic acid, suggesting that differences in lipid metabolism and tryptophan utilization pathways are linked to specific maternal diets. We also identified two latent metabolic groups not associated with either diet treatment: one metabolome associated with higher fasting glucose, and the other associated with higher fasting TGs after 7 weeks on either diet. Our study underscores the importance of utilizing dietary approaches to optimize maternal-fetal health outcomes in GDM treatment.
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
