Phutthacharoen, K.; Llanos-López, N.A.; Toshe, R.; Noisripoom, W.; Khonsanit, A.; Luangsa-ard, J.J.; Hyde, K.D.; Ebada, S.S.; Stadler, M. Bioactive Bioxanthracene and Cyclodepsipeptides from the Entomopathogenic Fungus Blackwellomyces roseostromatus BCC56290. Antibiotics2024, 13, 585.
Phutthacharoen, K.; Llanos-López, N.A.; Toshe, R.; Noisripoom, W.; Khonsanit, A.; Luangsa-ard, J.J.; Hyde, K.D.; Ebada, S.S.; Stadler, M. Bioactive Bioxanthracene and Cyclodepsipeptides from the Entomopathogenic Fungus Blackwellomyces roseostromatus BCC56290. Antibiotics 2024, 13, 585.
Phutthacharoen, K.; Llanos-López, N.A.; Toshe, R.; Noisripoom, W.; Khonsanit, A.; Luangsa-ard, J.J.; Hyde, K.D.; Ebada, S.S.; Stadler, M. Bioactive Bioxanthracene and Cyclodepsipeptides from the Entomopathogenic Fungus Blackwellomyces roseostromatus BCC56290. Antibiotics2024, 13, 585.
Phutthacharoen, K.; Llanos-López, N.A.; Toshe, R.; Noisripoom, W.; Khonsanit, A.; Luangsa-ard, J.J.; Hyde, K.D.; Ebada, S.S.; Stadler, M. Bioactive Bioxanthracene and Cyclodepsipeptides from the Entomopathogenic Fungus Blackwellomyces roseostromatus BCC56290. Antibiotics 2024, 13, 585.
Abstract
In the course of our ongoing research targeting the identification of potential biocontrol agents from entomopathogenic fungi (EPF), we explored a solid-state rice fungal extract of Blackwellomyces roseostromatus BCC56290 derived from infected lepidopteran larvae. Chemical and biological prospections afforded four unprecedently reported natural products differentiated into one dimeric naphthopyran bioxanthracene ES-242 derivative (1) and three cyclodepsipeptides (2-4) in addition to two known cyclodepsipeptides, cardinalisamides B (5) and C (6). Chemical structures of the isolated compounds were elucidated through comprehensive 1D/2D NMR and HR-ESI-MS data together with comparisons to the reported literature. The absolute configuration of the isolated cyclodepsipeptide was determined using Marfey’s method. All isolated compounds were assessed for their antimicrobial, cytotoxic and nematicidal activities with some compounds revealed significant activities.
Biology and Life Sciences, Biology and Biotechnology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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