Version 1
: Received: 20 June 2024 / Approved: 21 June 2024 / Online: 21 June 2024 (16:52:11 CEST)
How to cite:
Sagrero-Fabela, N.; Chávez-Mireles, R.; Salazar-Camarena, D. C.; Palafox-Sánchez, C. A. Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus. Preprints2024, 2024061533. https://doi.org/10.20944/preprints202406.1533.v1
Sagrero-Fabela, N.; Chávez-Mireles, R.; Salazar-Camarena, D. C.; Palafox-Sánchez, C. A. Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus. Preprints 2024, 2024061533. https://doi.org/10.20944/preprints202406.1533.v1
Sagrero-Fabela, N.; Chávez-Mireles, R.; Salazar-Camarena, D. C.; Palafox-Sánchez, C. A. Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus. Preprints2024, 2024061533. https://doi.org/10.20944/preprints202406.1533.v1
APA Style
Sagrero-Fabela, N., Chávez-Mireles, R., Salazar-Camarena, D. C., & Palafox-Sánchez, C. A. (2024). Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus. Preprints. https://doi.org/10.20944/preprints202406.1533.v1
Chicago/Turabian Style
Sagrero-Fabela, N., Diana Celeste Salazar-Camarena and Claudia Azucena Palafox-Sánchez. 2024 "Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus" Preprints. https://doi.org/10.20944/preprints202406.1533.v1
Abstract
Despite advances in our knowledge of systemic lupus erythematosus (SLE) has increased over time, there are still many challenges in deciphering the precise mechanisms involved in the development and progression of the disease. Recent evidence has raised questions about the effectiveness of the programmed cell death protein 1 (PD-1) in suppressing autoreactive CD4+ T cells during the autoimmune response. Research has ventured into investigate the potential impact of PD-1 on various CD4+ T cell subpopulations, including T follicular helper (Tfh) cells, circulating Tfh (cTfh) cells, and T peripheral helper (Tph) cells, all of which exhibit substantial PD-1 expression and have been closely related with several autoimmune disorders including SLE. This review aims to highlight the complex role of PD-1 in autoimmunity and emphasizes the imperative for further research to elucidate its functions during autoreactive T-cell response. Additionally, we address the potential of PD-1 or its ligands as a possible therapeutic target in SLE.
Keywords
PD-1; PD-L1/PD-L2; Systemic lupus erythematosus; T follicular helper (Tfh) cells; T peripheral helper (Tph) cells.
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
