Version 1
: Received: 20 June 2024 / Approved: 20 June 2024 / Online: 21 June 2024 (16:51:35 CEST)
How to cite:
Kizilaslan, M.; Arzik, Y.; Behrem, S.; Yavuz, E.; White, S. N.; Cinar, M. U. Unravelling the Genetic Architecture of Serum Biochemical Indicators in Sheep. Preprints2024, 2024061548. https://doi.org/10.20944/preprints202406.1548.v1
Kizilaslan, M.; Arzik, Y.; Behrem, S.; Yavuz, E.; White, S. N.; Cinar, M. U. Unravelling the Genetic Architecture of Serum Biochemical Indicators in Sheep. Preprints 2024, 2024061548. https://doi.org/10.20944/preprints202406.1548.v1
Kizilaslan, M.; Arzik, Y.; Behrem, S.; Yavuz, E.; White, S. N.; Cinar, M. U. Unravelling the Genetic Architecture of Serum Biochemical Indicators in Sheep. Preprints2024, 2024061548. https://doi.org/10.20944/preprints202406.1548.v1
APA Style
Kizilaslan, M., Arzik, Y., Behrem, S., Yavuz, E., White, S. N., & Cinar, M. U. (2024). Unravelling the Genetic Architecture of Serum Biochemical Indicators in Sheep. Preprints. https://doi.org/10.20944/preprints202406.1548.v1
Chicago/Turabian Style
Kizilaslan, M., Stephen N. White and Mehmet Ulas Cinar. 2024 "Unravelling the Genetic Architecture of Serum Biochemical Indicators in Sheep" Preprints. https://doi.org/10.20944/preprints202406.1548.v1
Abstract
Serum biochemical indicators serve as vital proxies that reflect the physiological state and functions of different organs. The genetic parameters and molecular mechanisms underlying serum biochemical indicators of sheep (Ovis aries) have not been well understood. Therefore, the aim of the present study was to identify genetic architecture and genomic loci underlying ten serum biochemical indicators in sheep, including alanine transaminase, aspartate transferase, lactate dehydrogenase, cholesterol, glucose, phosphorus, calcium, creatinine, urea concentrations and total protein levels. We implemented genetic parameter estimations and GWAS for each trait in 422 Akkaraman lambs. Overall, low to moderate heritability estimates were found, in the range 0.14–0.55. Additionally, low to high genetic correlations were observed among traits. In total, 23 SNP loci were associated with serum biochemical indicators leading to 19 genes . These are SPTA1, MGST2, CACUL1, IGFBP7, PARD3, PHB1, SLC15A5, TRIM35, RGS6, NUP93, CNTNAP2, SLC7A11, B3GALT5, DPP10, HST2ST1, NRP1, LRP1B, MAP3K9, ENSOARG00020040484.1 as well as LOC101103187, LOC101117162, LOC105611309 and LOC101118029. To our knowledge, these data provide the first association between SPTA1 and serum cholesterol and between ENSOARG00020040484.1 and serum glucose. The current findings provide a comprehensive inventory of the relationships between serum biochemical parameters, genetic variants, and disease-relevant characteristics. This information may facilitate the identification of therapeutic targets and fluid biomarkers and establish a strong framework for comprehending the pathobiology of complex diseases as well as providing targets for sheep genetic improvement programmes.
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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