Version 1
: Received: 21 June 2024 / Approved: 22 June 2024 / Online: 24 June 2024 (12:16:01 CEST)
How to cite:
Jaafari, A.; Rizzo, O.; Mansour, S.; Chbabou, A.; Trepant, A.-L.; Attou, R.; Mathey, C. When Infection Lurks Behind Malignancy: A Unique Case of Primary Bone Lymphoma Mimicking Infectious Process in the Spine. Preprints2024, 2024061574. https://doi.org/10.20944/preprints202406.1574.v1
Jaafari, A.; Rizzo, O.; Mansour, S.; Chbabou, A.; Trepant, A.-L.; Attou, R.; Mathey, C. When Infection Lurks Behind Malignancy: A Unique Case of Primary Bone Lymphoma Mimicking Infectious Process in the Spine. Preprints 2024, 2024061574. https://doi.org/10.20944/preprints202406.1574.v1
Jaafari, A.; Rizzo, O.; Mansour, S.; Chbabou, A.; Trepant, A.-L.; Attou, R.; Mathey, C. When Infection Lurks Behind Malignancy: A Unique Case of Primary Bone Lymphoma Mimicking Infectious Process in the Spine. Preprints2024, 2024061574. https://doi.org/10.20944/preprints202406.1574.v1
APA Style
Jaafari, A., Rizzo, O., Mansour, S., Chbabou, A., Trepant, A. L., Attou, R., & Mathey, C. (2024). When Infection Lurks Behind Malignancy: A Unique Case of Primary Bone Lymphoma Mimicking Infectious Process in the Spine. Preprints. https://doi.org/10.20944/preprints202406.1574.v1
Chicago/Turabian Style
Jaafari, A., Rachid Attou and Céline Mathey. 2024 "When Infection Lurks Behind Malignancy: A Unique Case of Primary Bone Lymphoma Mimicking Infectious Process in the Spine" Preprints. https://doi.org/10.20944/preprints202406.1574.v1
Abstract
Primary bone lymphoma of the spine (PBL) is a rare entity and the most shared type of non-Hodgkin lymphoma (LNH) appearing in bone lesions deprived of nodal or extra-nodal in-volvement and accounting for approximately 2% of all lymphomas. Most PBL are diffuse large B-cell lymphomas (DLBCL) and commonly involve the appendicular skeleton. Due to its atypical location and non-specific clinical imaging features mimicking certain neoplastic or infectious processes, this pathology may be misdiagnosed, thus complicating and delaying diagnosis. Our case reports a patient in her sixties who had been suffering from chronic low back pain for a year, and had gradually started to develop cruralgia and fever. She underwent a blood sample, magnetic resonance imaging (MRI), and positron emission tomography (18F-FDG-PET/CT) which revealed significant inflammatory syndrome, a pattern of spondylodiscitis at the L3-L4 level associated with morphological and metabolic invasion extending posteriorly, raising suspicion of epiduritis. No other lesions were found on the rest of the body. Neurosurgical management was performed and a biopsy was made. Histological results showed aggressive and diffuse large B-cell lymphoma, suggesting a diagnosis of PBL. This case highlights the first case of spondylodiscitis mimicking PBL in the lumbar spine, the intricacies of the diagnostic work-up, and the complexity of discriminating with an infectious process in the spine, as both have a similar, non-specific clinical presentation with different prognosis and therapeutic management.
Keywords
Primary bone lymphoma; Diffuse large B-cell lymphoma; Spondylodiscitis; 18F-FDG-PET/CT; MRI.
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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