Version 1
: Received: 28 June 2024 / Approved: 28 June 2024 / Online: 28 June 2024 (20:01:41 CEST)
How to cite:
Mochel, J. Renin-Angiotensin Aldosterone System Modulation and Cardiovascular-Kidney-Metabolic Health. Preprints2024, 2024062075. https://doi.org/10.20944/preprints202406.2075.v1
Mochel, J. Renin-Angiotensin Aldosterone System Modulation and Cardiovascular-Kidney-Metabolic Health. Preprints 2024, 2024062075. https://doi.org/10.20944/preprints202406.2075.v1
Mochel, J. Renin-Angiotensin Aldosterone System Modulation and Cardiovascular-Kidney-Metabolic Health. Preprints2024, 2024062075. https://doi.org/10.20944/preprints202406.2075.v1
APA Style
Mochel, J. (2024). Renin-Angiotensin Aldosterone System Modulation and Cardiovascular-Kidney-Metabolic Health. Preprints. https://doi.org/10.20944/preprints202406.2075.v1
Chicago/Turabian Style
Mochel, J. 2024 "Renin-Angiotensin Aldosterone System Modulation and Cardiovascular-Kidney-Metabolic Health" Preprints. https://doi.org/10.20944/preprints202406.2075.v1
Abstract
Similar to humans, the renin-angiotensin-aldosterone system (RAAS) plays a key role in regulating blood pressure and body fluid homeostasis in dogs and cats. The classical RAAS pathway, which involves the conversion of angiotensin I to angiotensin II by the angiotensin converting enzyme (ACE), leads to aldosterone production and associated maladaptive effects in cardiovascular and renal diseases. Recent studies have highlighted the alternative RAAS pathway, which counteracts these effects through angiotensin 1-7, promoting vasodilation and reducing inflammation. Beyond RAAS modulation, RAAS inhibitors have been shown to exert significant anti-inflammatory properties. This is particularly relevant given the American Heart Association's recent focus on Cardiovascular-Kidney-Metabolic (CKM) health, which emphasizes the interconnected risks of cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes, and obesity. These conditions share common pathophysiological pathways, including chronic inflammation, oxidative stress, and metabolic dysregulation. Advances in biomedical research, including the development of adult stem cell-derived canine organoids, provide impetus to study the effects of RAAS modulators and new CVD drugs on CKM health, with a focus on epithelial inflammation within the context of One Health.
Keywords
RAAS, Cardiorenal Metabolic Diseases, Inflammation, One Health.
Subject
Medicine and Pharmacology, Veterinary Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
