Version 1
: Received: 28 June 2024 / Approved: 1 July 2024 / Online: 1 July 2024 (13:12:39 CEST)
How to cite:
Goudra, B.; Brohan, M.; Brohan, J. Remimazolam and its place in the current landscape of procedural sedation and general anesthesia. Preprints2024, 2024070081. https://doi.org/10.20944/preprints202407.0081.v1
Goudra, B.; Brohan, M.; Brohan, J. Remimazolam and its place in the current landscape of procedural sedation and general anesthesia. Preprints 2024, 2024070081. https://doi.org/10.20944/preprints202407.0081.v1
Goudra, B.; Brohan, M.; Brohan, J. Remimazolam and its place in the current landscape of procedural sedation and general anesthesia. Preprints2024, 2024070081. https://doi.org/10.20944/preprints202407.0081.v1
APA Style
Goudra, B., Brohan, M., & Brohan, J. (2024). Remimazolam and its place in the current landscape of procedural sedation and general anesthesia. Preprints. https://doi.org/10.20944/preprints202407.0081.v1
Chicago/Turabian Style
Goudra, B., Matthew Brohan and Janette Brohan. 2024 "Remimazolam and its place in the current landscape of procedural sedation and general anesthesia" Preprints. https://doi.org/10.20944/preprints202407.0081.v1
Abstract
Remimazolam was derived from its parent compound by adding an ester linkage into its structure, so that the drug becomes a substrate for ester metabolism. As a result, it undergoes organ independent ester hydrolysis, although the clinical benefits in terms of shorter recovery are not uniformly observed in clinical practice. Remimazolam is mainly tested in procedural sedation. In comparison to propofol, the current gold standard for procedural sedation, its proposed attractiveness is shorter wake-up times and a clear-headed recovery Its clear advantage over propofol is better hemodynamic stability, lack of pain on injection and availability of a reversal agent in the form of flumazenil. Data on patient and proceduralist’s satisfaction are lacking. Remimazolam is also used for induction and maintenance of general anesthesia in Japan (where it is approved for this purpose). In this scenario, it is not clear if it can achieve the same degree of lack of recall as propofol. The use of remimazolam in obstetrics, pediatrics and in high-risk population is an emerging area.
Keywords
General Anesthesia
Subject
Medicine and Pharmacology, Anesthesiology and Pain Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
