Proposing Bromo-Epi-Androsterone for Neurologic Long-COVID

Coad Thomas Dow

doi:10.20944/preprints202407.0115.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 30 June 2024 / Approved: 1 July 2024 / Online: 1 July 2024 (17:58:01 CEST)

The neurologic effects of long-COVID are a therapeutic challenge. This article discusses the immunologic manifestations of long-COVID and proposes a non-androgenic, synthetic analog of dehydroepiandrosterone (DHEA), bromo-epi-androsterone (BEA), as a candidate for clinical trials for this exigent collection of neurologic conditions. Moreover, because there is an association between long-COVID and Alzheimer’s disease, the evaluation of BEA in long-COVID may serve as a proxy for its effect on neuroinflammatory biomarkers of Alzheimer’s disease that are shared with long-COVID.

SARS-CoV-2; Long-COVID; brain fog, immune dysregulation, dehydroepiandrosterone (DHEA); bromo-epi-androsterone (BEA); biomarkers; neuroinflammation; Alzheimer’s.

Medicine and Pharmacology, Epidemiology and Infectious Diseases

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Proposing Bromo-Epi-Androsterone for Neurologic Long-COVID

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