Version 1
: Received: 29 June 2024 / Approved: 1 July 2024 / Online: 1 July 2024 (17:52:25 CEST)
How to cite:
Boxhammer, E.; Zauner, S.; Kraus, J.; Dinges, C.; Schernthaner, C.; Danmayr, F.; Kolbitsch, T.; Granitz, C.; Motloch, L. J.; Hammerer, M.; Lichtenauer, M.; Hoppe, U. C.; Strohmer, B. Harmonizing Heartbeats: The Mosaic of Cardiac Resynchronization Therapy Responders — A Comprehensive Exploration of Diverse Criteria and Predictors. Preprints2024, 2024070116. https://doi.org/10.20944/preprints202407.0116.v1
Boxhammer, E.; Zauner, S.; Kraus, J.; Dinges, C.; Schernthaner, C.; Danmayr, F.; Kolbitsch, T.; Granitz, C.; Motloch, L. J.; Hammerer, M.; Lichtenauer, M.; Hoppe, U. C.; Strohmer, B. Harmonizing Heartbeats: The Mosaic of Cardiac Resynchronization Therapy Responders — A Comprehensive Exploration of Diverse Criteria and Predictors. Preprints 2024, 2024070116. https://doi.org/10.20944/preprints202407.0116.v1
Boxhammer, E.; Zauner, S.; Kraus, J.; Dinges, C.; Schernthaner, C.; Danmayr, F.; Kolbitsch, T.; Granitz, C.; Motloch, L. J.; Hammerer, M.; Lichtenauer, M.; Hoppe, U. C.; Strohmer, B. Harmonizing Heartbeats: The Mosaic of Cardiac Resynchronization Therapy Responders — A Comprehensive Exploration of Diverse Criteria and Predictors. Preprints2024, 2024070116. https://doi.org/10.20944/preprints202407.0116.v1
APA Style
Boxhammer, E., Zauner, S., Kraus, J., Dinges, C., Schernthaner, C., Danmayr, F., Kolbitsch, T., Granitz, C., Motloch, L. J., Hammerer, M., Lichtenauer, M., Hoppe, U. C., & Strohmer, B. (2024). Harmonizing Heartbeats: The Mosaic of Cardiac Resynchronization Therapy Responders — A Comprehensive Exploration of Diverse Criteria and Predictors. Preprints. https://doi.org/10.20944/preprints202407.0116.v1
Chicago/Turabian Style
Boxhammer, E., Uta C Hoppe and Bernhard Strohmer. 2024 "Harmonizing Heartbeats: The Mosaic of Cardiac Resynchronization Therapy Responders — A Comprehensive Exploration of Diverse Criteria and Predictors" Preprints. https://doi.org/10.20944/preprints202407.0116.v1
Abstract
Background: Heart failure (HF) remains a challenging healthcare issue, necessitating innovative therapies like cardiac resynchronization-defibrillation therapy (CRT-D). However, defining CRT-D responders lacks uniformity, impeding effective clinical evaluation. This study explores diverse CRT-D responder definitions, encompassing functional, echocardiographic, and laboratory criteria.
Materials & Methods: A single-center study involving 132 CRT-D patients scrutinized responder criteria, including NYHA stage, LVEF increase, and proBNP decrease. Statistical analyses, such as Kaplan–Meier curves and Cox hazard regression, were employed to evaluate responder characteristics and survival outcomes.
Results: Responder rates varied across criteria, revealing nuanced patient profiles. CRT-D responders, defined by NYHA decrease, LVEF increase, or proBNP decrease, exhibit improved survival rates after 2 and 3 years (p < 0.050). Young age, absence of recent myocardial infarction, and normal right ventricular, echocardiographic parameters emerge as predictors for positive response. In part, drug-based HF therapy correlates with increased responder rates. Cox regression identified LVEF ≥ 5% and proBNP decrease ≥ 25% as independent predictors of extended survival.
Conclusions: CRT-D responder definitions exhibit considerable variability, emphasizing the need for a nuanced, patient-centered approach. Factors like right ventricular function, drug therapy, atrial fibrillation, and renal function influence responses. The study enriches our understanding of CRT-D response, contributing to the foundation for personalized HF management.
Keywords
cardiac resynchronization therapy; heart failure; left ventricular ejection fraction; proBNP; responder status
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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