Version 1
: Received: 2 July 2024 / Approved: 2 July 2024 / Online: 2 July 2024 (13:12:24 CEST)
How to cite:
de Souza, B. Z.; Facchi, D. P.; Facchi, S. P.; Teodoro, C. F.; de Almeida, D. A.; Popat, K. C.; Kipper, M. J.; Bonafé, E. G.; Martins, A. F. Electrospun Fibers of Ecovio® Polymer Blends with Antimicrobial Tea Tree Essential Oil: Enhanced Chemical and Biological Properties. Preprints2024, 2024070242. https://doi.org/10.20944/preprints202407.0242.v1
de Souza, B. Z.; Facchi, D. P.; Facchi, S. P.; Teodoro, C. F.; de Almeida, D. A.; Popat, K. C.; Kipper, M. J.; Bonafé, E. G.; Martins, A. F. Electrospun Fibers of Ecovio® Polymer Blends with Antimicrobial Tea Tree Essential Oil: Enhanced Chemical and Biological Properties. Preprints 2024, 2024070242. https://doi.org/10.20944/preprints202407.0242.v1
de Souza, B. Z.; Facchi, D. P.; Facchi, S. P.; Teodoro, C. F.; de Almeida, D. A.; Popat, K. C.; Kipper, M. J.; Bonafé, E. G.; Martins, A. F. Electrospun Fibers of Ecovio® Polymer Blends with Antimicrobial Tea Tree Essential Oil: Enhanced Chemical and Biological Properties. Preprints2024, 2024070242. https://doi.org/10.20944/preprints202407.0242.v1
APA Style
de Souza, B. Z., Facchi, D. P., Facchi, S. P., Teodoro, C. F., de Almeida, D. A., Popat, K. C., Kipper, M. J., Bonafé, E. G., & Martins, A. F. (2024). Electrospun Fibers of Ecovio® Polymer Blends with Antimicrobial Tea Tree Essential Oil: Enhanced Chemical and Biological Properties. Preprints. https://doi.org/10.20944/preprints202407.0242.v1
Chicago/Turabian Style
de Souza, B. Z., Elton G. Bonafé and Alessandro F. Martins. 2024 "Electrospun Fibers of Ecovio® Polymer Blends with Antimicrobial Tea Tree Essential Oil: Enhanced Chemical and Biological Properties" Preprints. https://doi.org/10.20944/preprints202407.0242.v1
Abstract
This study presents, for the first time, the development of fibers with favorable properties for biodegradable wound dressings made from the Ecovio® (EC) polymer blend, composed of poly(lactic acid) (PLA) and poly(butylene adipate-co-terephthalate) (PBAT), incorporated with tea tree essential oil (TTE). TTE presented antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus, achieving minimal inhibitory concentrations of 15 and 7.5 mg/mL, respectively. The TTE was mixed with EC in a binary chloroform and formic acid (85/15 v/v) mixture, leading to homogeneous and wettable fibers by electrospinning. The EC/TTE fibers were characterized confirming the TTE in the fibers. The tests showed that TTE (0.5, 1.0 or 1.5 mL) improved the polymer blend electrospinnability. TTE (1.5 mL or 75 w% concerning the EC) lead to homogeneous fibers with an average diameter of 278 nm. TTE (75 w%) increased the wettability of the EC fibers from 120±2° to 69±1°. Preliminary bacterial adhesion and proliferation assays demonstrated that the EC/TTE fibers have anti-adhesive activity e seems to be more toxic against P. aeruginosa compared to S. aureus after 24 hours of incubation. Compatibility tests with human blood indicated that the EC/TTE fibers accelerate blood coagulation. The EC/TTE fibers exhibit promising chemical and biological properties (in vitro) for the development of wound dressings.
Chemistry and Materials Science, Materials Science and Technology
Copyright:
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