Salidroside as a Modulator of Bone Metabolism: Insight Into the Active Constituent of Rhodiola rosea

How to cite: Wojdasiewicz, P.; Brodacki, S.; Cieślicka, E.; Turczyn, P.; Poniatowski, Ł. A.; Ławniczak, W.; Olczak, M.; Stolarczyk, E. U.; Wróbel, E.; Mikulska, A.; Lach-Gruba, A.; Żuk, B.; Romanowska-Próchnicka, K.; Szukiewicz, D. Salidroside as a Modulator of Bone Metabolism: Insight Into the Active Constituent of Rhodiola rosea. Preprints 2024, 2024070257. https://doi.org/10.20944/preprints202407.0257.v1 Wojdasiewicz, P.; Brodacki, S.; Cieślicka, E.; Turczyn, P.; Poniatowski, Ł. A.; Ławniczak, W.; Olczak, M.; Stolarczyk, E. U.; Wróbel, E.; Mikulska, A.; Lach-Gruba, A.; Żuk, B.; Romanowska-Próchnicka, K.; Szukiewicz, D. Salidroside as a Modulator of Bone Metabolism: Insight Into the Active Constituent of Rhodiola rosea. Preprints 2024, 2024070257. https://doi.org/10.20944/preprints202407.0257.v1

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MDPI and ACS Style

Wojdasiewicz, P.; Brodacki, S.; Cieślicka, E.; Turczyn, P.; Poniatowski, Ł. A.; Ławniczak, W.; Olczak, M.; Stolarczyk, E. U.; Wróbel, E.; Mikulska, A.; Lach-Gruba, A.; Żuk, B.; Romanowska-Próchnicka, K.; Szukiewicz, D. Salidroside as a Modulator of Bone Metabolism: Insight Into the Active Constituent of Rhodiola rosea. Preprints 2024, 2024070257. https://doi.org/10.20944/preprints202407.0257.v1

APA Style

Wojdasiewicz, P., Brodacki, S., Cieślicka, E., Turczyn, P., Poniatowski, Ł. A., Ławniczak, W., Olczak, M., Stolarczyk, E. U., Wróbel, E., Mikulska, A., Lach-Gruba, A., Żuk, B., Romanowska-Próchnicka, K., & Szukiewicz, D. (2024). Salidroside as a Modulator of Bone Metabolism: Insight Into the Active Constituent of <em>Rhodiola rosea</em>. Preprints. https://doi.org/10.20944/preprints202407.0257.v1

Chicago/Turabian Style

Wojdasiewicz, P., Katarzyna Romanowska-Próchnicka and Dariusz Szukiewicz. 2024 "Salidroside as a Modulator of Bone Metabolism: Insight Into the Active Constituent of <em>Rhodiola rosea</em>" Preprints. https://doi.org/10.20944/preprints202407.0257.v1

Abstract

Rhodiola rosea, a perennial herb from the Crassulaceae family, contains the bioactive compound salidroside, recognized as an adaptogen with significant therapeutic potential for bone metabolism. Salidroside promotes osteoblast proliferation and differentiation by activating critical signaling pathways, including bone morphogenetic protein-2 and adenosine monophosphate-activated protein kinase, essential for bone formation and growth. It enhances osteogenic activity by increasing alkaline phosphatase activity and mineralization markers, while upregulating key transcription factors such as runt-related transcription factor 2 and osterix. Additionally, salidroside facilitates angiogenesis via the hypoxia-inducible factor 1-alpha and vascular endothelial growth factor pathway, crucial for coupling bone formation with vascular support. Its antioxidant properties offer protection against bone loss by reducing oxidative stress and promoting osteogenic differentiation through the nuclear factor erythroid 2–related factor 2 pathway. Salidroside's ability to counteract the negative effects of glucocorticoids on bone cells and prevent steroid-induced osteonecrosis, along with its anti-inflammatory properties, enhances its potential in treating conditions like osteoarthritis. These attributes underscore its multifaceted role in bone metabolism. This article reviews the literature, including in vitro and in vivo studies primarily on rodent models, demonstrating salidroside's efficacy in mitigating bone loss, preserving bone microarchitecture, and accelerating fracture healing. Future research directions to explore salidroside’s applications in bone-related diseases are also highlighted.

Keywords

salidroside; adaptogens; bone metabolism; osteoporosis; Rhodiola rosea; bone loss; fracture healing; osteoblasts

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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