Version 1
: Received: 2 July 2024 / Approved: 2 July 2024 / Online: 3 July 2024 (16:29:13 CEST)
How to cite:
Marsico, M.; Azari, R.; Curcio, M.; Teghil, R.; Triunfo, M.; Falabella, P.; Boccaccini, A. R.; De Bonis, A. Enhancing the Antibacterial Properties of Chitosan Coatings: Ag@chitosan and Chitosan from Insects. Preprints2024, 2024070301. https://doi.org/10.20944/preprints202407.0301.v1
Marsico, M.; Azari, R.; Curcio, M.; Teghil, R.; Triunfo, M.; Falabella, P.; Boccaccini, A. R.; De Bonis, A. Enhancing the Antibacterial Properties of Chitosan Coatings: Ag@chitosan and Chitosan from Insects. Preprints 2024, 2024070301. https://doi.org/10.20944/preprints202407.0301.v1
Marsico, M.; Azari, R.; Curcio, M.; Teghil, R.; Triunfo, M.; Falabella, P.; Boccaccini, A. R.; De Bonis, A. Enhancing the Antibacterial Properties of Chitosan Coatings: Ag@chitosan and Chitosan from Insects. Preprints2024, 2024070301. https://doi.org/10.20944/preprints202407.0301.v1
APA Style
Marsico, M., Azari, R., Curcio, M., Teghil, R., Triunfo, M., Falabella, P., Boccaccini, A. R., & De Bonis, A. (2024). Enhancing the Antibacterial Properties of Chitosan Coatings: Ag@chitosan and Chitosan from Insects. Preprints. https://doi.org/10.20944/preprints202407.0301.v1
Chicago/Turabian Style
Marsico, M., Aldo Roberto Boccaccini and Angela De Bonis. 2024 "Enhancing the Antibacterial Properties of Chitosan Coatings: Ag@chitosan and Chitosan from Insects" Preprints. https://doi.org/10.20944/preprints202407.0301.v1
Abstract
In this study electrophoretic deposition (EPD) technique is used to prepare chitosan-based coatings with enhanced antibacterial activity suitable for bone implants applications. We designed, prepared and compared physic-chemical and biological properties of coatings obtained with commercial chitosan, chitosan enriched with silver nanoparticles and chitosan obtained from insects. With the aim to consider the sustainability issue, silver nanoparticles were directly prepared in the chitosan solution by laser ablation in liquid technique, avoiding the use of chemicals and limiting the production of wastes. Moreover, a sustainable source of chitosan such as Hermetia Illucens exuviae was considered. The EPD process was optimized by adjusting parameters like voltage and deposition time to achieve ideal coating thickness and adhesion. The prepared films were characterized by spectroscopic and microscopic techniques such as SEM, XRD, and FTIR. Antimicrobial tests against E. coli and S. aureus revealed that silver nanoparticles enhanced the antibacterial properties of the polymer, whereas biological evaluation using the WST8 test on MG63 human osteoblasts-like cells showed that all coatings are non-toxic. Finally, chitosan obtained from insect showed comparable properties with respect to the commercial polymer, suggesting it could replace seafood-derived chitosan in biomedical applications, whereas the Ag@chitosan composite demonstrated superior antibacterial activity without compromising its biocompatibility.
Chemistry and Materials Science, Surfaces, Coatings and Films
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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