Version 1
: Received: 3 July 2024 / Approved: 4 July 2024 / Online: 4 July 2024 (11:48:50 CEST)
How to cite:
Fazzio, A.; Caponnetto, A.; Ferrara, C.; Purrello, M.; Di Pietro, C.; Battaglia, R. From Germ Cells to Implantation: The Role of Extracellular Vesicles. Preprints2024, 2024070445. https://doi.org/10.20944/preprints202407.0445.v1
Fazzio, A.; Caponnetto, A.; Ferrara, C.; Purrello, M.; Di Pietro, C.; Battaglia, R. From Germ Cells to Implantation: The Role of Extracellular Vesicles. Preprints 2024, 2024070445. https://doi.org/10.20944/preprints202407.0445.v1
Fazzio, A.; Caponnetto, A.; Ferrara, C.; Purrello, M.; Di Pietro, C.; Battaglia, R. From Germ Cells to Implantation: The Role of Extracellular Vesicles. Preprints2024, 2024070445. https://doi.org/10.20944/preprints202407.0445.v1
APA Style
Fazzio, A., Caponnetto, A., Ferrara, C., Purrello, M., Di Pietro, C., & Battaglia, R. (2024). From Germ Cells to Implantation: The Role of Extracellular Vesicles. Preprints. https://doi.org/10.20944/preprints202407.0445.v1
Chicago/Turabian Style
Fazzio, A., Cinzia Di Pietro and Rosalia Battaglia. 2024 "From Germ Cells to Implantation: The Role of Extracellular Vesicles" Preprints. https://doi.org/10.20944/preprints202407.0445.v1
Abstract
Extracellular vesicles represent a large heterogeneous class of near and long-distance intercellular communication mediators, released by both prokaryotic and eukaryotic cells. Specifically, the scientific community has shown a growing interest in exosomes, which are nano-sized vesicles with an endosomal origin. Not so long ago, the physiological goal of exosome generation was largely unknown and required more investigation; at first, it was hypothesized that exosomes are able to remove excess, rejects and unnecessary constituents from cells to preserve cellular homeostasis. However, thanks to recent studies, the central role of exosomes in regulating cellular dialogue has emerged. Exosomes act as vectors on cell-cell signaling by their cargo, proteins, lipids, and nucleic acids, and influence physiological and pathological processes. The findings on exosomes are widespread in a large spectrum of biomedical applications from diagnosis and prognosis to thera-pies. In this review, we describe exosome biogenesis and the current methods for their isolation and characterization, emphasizing the role of their cargo in female reproductive processes, from gametogenesis to implantation, and the potential involvement in human female disorders.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
