Version 1
: Received: 4 July 2024 / Approved: 4 July 2024 / Online: 4 July 2024 (12:32:29 CEST)
How to cite:
Ma, X.; Zeng, J.; Xiao, W.; Li, W.; Cheng, J.; Lin, J. Relationship Between Pyochelin and Pseudomonas quinolone signal in Pseudomonas aeruginosa: A Direction for Future Research. Preprints2024, 2024070447. https://doi.org/10.20944/preprints202407.0447.v1
Ma, X.; Zeng, J.; Xiao, W.; Li, W.; Cheng, J.; Lin, J. Relationship Between Pyochelin and Pseudomonas quinolone signal in Pseudomonas aeruginosa: A Direction for Future Research. Preprints 2024, 2024070447. https://doi.org/10.20944/preprints202407.0447.v1
Ma, X.; Zeng, J.; Xiao, W.; Li, W.; Cheng, J.; Lin, J. Relationship Between Pyochelin and Pseudomonas quinolone signal in Pseudomonas aeruginosa: A Direction for Future Research. Preprints2024, 2024070447. https://doi.org/10.20944/preprints202407.0447.v1
APA Style
Ma, X., Zeng, J., Xiao, W., Li, W., Cheng, J., & Lin, J. (2024). Relationship Between Pyochelin and Pseudomonas quinolone signal in Pseudomonas aeruginosa: A Direction for Future Research. Preprints. https://doi.org/10.20944/preprints202407.0447.v1
Chicago/Turabian Style
Ma, X., Juanli Cheng and Jinshui Lin. 2024 "Relationship Between Pyochelin and Pseudomonas quinolone signal in Pseudomonas aeruginosa: A Direction for Future Research" Preprints. https://doi.org/10.20944/preprints202407.0447.v1
Abstract
Pseudomonas aeruginosa is an opportunistic pathogen that requires iron to survive in the host; however, the host immune system limits the availability of iron. Pyochelin (PCH) is a major siderophore produced by P. aeruginosa during infection, which can help P. aeruginosa survive in an iron-restricted environment and cause infection. The infection activity of P. aeruginosa is regulated by the Pseudomonas quinolone signal (PQS) quorum-sensing system. The system uses 2-heptyl-3-hydroxy-4-quinolone (PQS) or its precursor, 2-heptyl-4-quinolone (HHQ), as the signal molecule. PQS can control specific life processes such as mediating quorum sensing, cytotoxicity, and iron acquisition. This review summarizes the biosynthesis of PCH and PQS, the shared transport system of PCH and PQS, and the regulatory relationship between PCH and PQS. The correlation between the PQS and PCH is emphasized to provide a new direction for future research.
Keywords
Pseudomonas aeruginosa; quorum sensing; iron uptake; pyochelin; PQS; IQS; transporter
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
