Preprint Article Version 1 This version is not peer-reviewed

Evaluation of Psychosomatic, Respiratory, and Neurocognitive Health in COVID-19 Survivors 12 Months after ICU Discharge

Nicolas Germann
* ,
Daria Amozova
,
Kristina Göhl-Freyn
,
Tim Fischer
,
Manuel Frischknecht
,
Gian-Reto Kleger
,
Urs Pietsch
,
Miodrag Filipovic
,
Martin H. Brutsche
,
Thomas Frauenfelder
,
Christian R. Kahlert
,
Dagmar A. Schmid
,
Werner C. Albrich
Version 1 : Received: 4 July 2024 / Approved: 4 July 2024 / Online: 5 July 2024 (00:23:15 CEST)

How to cite: Germann, N.; Amozova, D.; Göhl-Freyn, K.; Fischer, T.; Frischknecht, M.; Kleger, G.-R.; Pietsch, U.; Filipovic, M.; Brutsche, M. H.; Frauenfelder, T.; Kahlert, C. R.; Schmid, D. A.; Albrich, W. C. Evaluation of Psychosomatic, Respiratory, and Neurocognitive Health in COVID-19 Survivors 12 Months after ICU Discharge. Preprints 2024, 2024070464. https://doi.org/10.20944/preprints202407.0464.v1 Germann, N.; Amozova, D.; Göhl-Freyn, K.; Fischer, T.; Frischknecht, M.; Kleger, G.-R.; Pietsch, U.; Filipovic, M.; Brutsche, M. H.; Frauenfelder, T.; Kahlert, C. R.; Schmid, D. A.; Albrich, W. C. Evaluation of Psychosomatic, Respiratory, and Neurocognitive Health in COVID-19 Survivors 12 Months after ICU Discharge. Preprints 2024, 2024070464. https://doi.org/10.20944/preprints202407.0464.v1

Abstract

Patients who survived critical COVID-19 frequently reported post-acute sequelae of COVID-19 (PASC) such as psychosomatic and neurocognitive health problems. The goal of this study was to identify clinical risk factors and other predictors for such long-term consequences in severely ill COVID-19 patients. Adult COVID-19 intensive care unit (ICU) survivors from August 2020 to May 2021 were enrolled. A broad range of clinical, laboratory and chest computed tomography (CT) data was collected during ICU stay. The association between ICU predictors and psychosomatic, respiratory and neurocognitive assessments 12 months after ICU discharge was analyzed using univariate regression analysis. In 17 patients (mean age 58.9 ± 11.4 years), laboratory markers (CRP, lymphocytes, hemoglobin), ICU severity (SOFA, SAPS II, need for mechanical ventilation), complications (ARDS), and lung CT data (ground-glass opacity) were promising predictors of depressive and anxiety symptoms, fatigue, and sleep problems. Recovery of psychosomatic health such as fatigue, depression and anxiety correlated with lower levels of inflammation and high hemoglobin levels. ARDS, mechanical ventilation and worse SOFA and SAPS II scores were further risk factors for depressive and anxiety symptoms. Our study identified novel associations such as pulmonary ground-glass opacity being positively associated with depression, anxiety, fatigue, and insomnia levels.

Keywords

COVID-19; Intensive Unit Care; ICU; Predictive Model; Psychosomatic Health

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.